PMID- 19422349
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 9
IP  - 5
DP  - 2009 May
TI  - Changes in pediatric renal transplantation after implementation of the revised 
      deceased donor kidney allocation policy.
PG  - 1237-42
LID - 10.1111/j.1600-6143.2009.02608.x [doi]
AB  - In October 2005, the United Network for Organ Sharing (UNOS) implemented a 
      revised allocation policy requiring that renal allografts from young deceased 
      donors (DDs) (<35 years old) be offered preferentially to pediatric patients (<18 
      years old). In this study, we compare the pre- and postpolicy quarterly pediatric 
      transplant statistics from 2000 to 2008. The mean number of pediatric renal 
      transplants with young DDs increased after policy implementation from 62.8 to 133 
      per quarter (p < 0.001), reflecting a change in the proportion of all transplants 
      from young DDs during the study period from 0.33 to 0.63 (p < 0.001). The mean 
      number of pediatric renal transplants from old DDs (> or =35 years old) decreased 
      from 22.4 to 2.6 per quarter (p < 0.001). The proportion of all pediatric renal 
      transplants from living donors decreased from 0.55 to 0.35 (p < 0.001). The 
      proportion from young DDs with five or six mismatched human leukocyte antigen 
      (HLA) loci increased from 0.16 to 0.36 (p < 0.001) while those with 0 to 4 HLA 
      mismatches increased from 0.18 to 0.27 (p < 0.001). Revision of UNOS policy has 
      increased the number of pediatric renal transplants with allografts from young 
      DDs, while increasing HLA-mismatched allografts and decreasing the number from 
      living donors.
FAU - Agarwal, S
AU  - Agarwal S
AD  - Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
FAU - Oak, N
AU  - Oak N
FAU - Siddique, J
AU  - Siddique J
FAU - Harland, R C
AU  - Harland RC
FAU - Abbo, E D
AU  - Abbo ED
LA  - eng
GR  - 231-00-0115/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Cadaver
MH  - Child
MH  - HLA Antigens/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/immunology/*statistics & numerical data
MH  - Patient Selection
MH  - Resource Allocation/methods/*trends
MH  - Tissue Donors/*statistics & numerical data
MH  - Transplantation, Homologous
EDAT- 2009/05/09 09:00
MHDA- 2009/07/30 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
AID - S1600-6135(22)01677-X [pii]
AID - 10.1111/j.1600-6143.2009.02608.x [doi]
PST - ppublish
SO  - Am J Transplant. 2009 May;9(5):1237-42. doi: 10.1111/j.1600-6143.2009.02608.x.