PMID- 19422394
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20240516
IS  - 1476-5381 (Electronic)
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 158
IP  - 1
DP  - 2009 Sep
TI  - Role of alpha 1- and beta 3-adrenoceptors in the modulation by SR59230A of the 
      effects of MDMA on body temperature in the mouse.
PG  - 259-66
LID - 10.1111/j.1476-5381.2009.00186.x [doi]
AB  - BACKGROUND AND PURPOSE: We have investigated the ability of the 
      beta(3)-adrenoceptor antagonist 
      1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4,-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol 
      hydrochloride (SR59230A) to affect the hyperthermia produced by 
      methylenedioxymethamphetamine (MDMA) in conscious mice and whether 
      alpha(1)-adrenoceptor antagonist actions are involved. EXPERIMENTAL APPROACH: 
      Mice were implanted with temperature probes under anaesthesia, and allowed 2 week 
      recovery. MDMA (20 mg x kg(-1)) was administered subcutaneously 30 min after 
      vehicle or test antagonist and effects on body temperature monitored by 
      telemetry. KEY RESULTS: Following vehicle, MDMA produced a slowly developing 
      hyperthermia, reaching a maximum increase of 1.8 degrees C at 130 min post 
      injection. A low concentration of SR59230A (0.5 mg x kg(-1)) produced a small but 
      significant attenuation of the slowly developing hyperthermia to MDMA. A high 
      concentration of SR59230A (5 mg x kg(-1)) revealed a significant and marked early 
      hypothermic reaction to MDMA, an effect that was mimicked by the 
      alpha(1)-adrenoceptor antagonist prazosin. Functional and ligand binding studies 
      revealed actions of SR59230A at alpha(1)-adrenoceptors. CONCLUSIONS AND 
      IMPLICATIONS: 
      1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4,-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol 
      hydrochloride in high concentrations modulates the hyperthermic actions of MDMA 
      in mice in two ways: by blocking an early alpha(1)-adrenoceptor-mediated 
      component to reveal a hypothermia, and by a small attenuation of the later 
      hyperthermic component which may possibly be beta(3)-adrenoceptor-mediated (this 
      seen with the low concentration of SR59230A). Hence, the major actions of 
      SR59230A in modulating the actions of MDMA on temperature involve 
      alpha(1)-adrenoceptor antagonism.
FAU - Bexis, Sotiria
AU  - Bexis S
AD  - Department of Physiology, Royal College of Surgeons in Ireland, Dublin, Ireland.
FAU - Docherty, James R
AU  - Docherty JR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090430
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate)
RN  - 0 (Adrenergic beta-3 Receptor Antagonists)
RN  - 0 (Propanolamines)
RN  - 0 (Receptors, Adrenergic, alpha-1)
RN  - 0 (Receptors, Adrenergic, beta-3)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - *Adrenergic beta-3 Receptor Antagonists
MH  - Animals
MH  - Body Temperature/drug effects/*physiology
MH  - Fever/chemically induced/prevention & control
MH  - In Vitro Techniques
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methyl-3,4-methylenedioxyamphetamine/antagonists & inhibitors/*toxicity
MH  - Propanolamines/*pharmacology/therapeutic use
MH  - Protein Binding/drug effects/physiology
MH  - Rats
MH  - Receptors, Adrenergic, alpha-1/*physiology
MH  - Receptors, Adrenergic, beta-3/*physiology
PMC - PMC2795232
EDAT- 2009/05/09 09:00
MHDA- 2010/05/21 06:00
PMCR- 2010/09/01
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - BPH186 [pii]
AID - 10.1111/j.1476-5381.2009.00186.x [doi]
PST - ppublish
SO  - Br J Pharmacol. 2009 Sep;158(1):259-66. doi: 10.1111/j.1476-5381.2009.00186.x. 
      Epub 2009 Apr 30.