PMID- 19424040
OWN - NLM
STAT- MEDLINE
DCOM- 20090708
LR  - 20090508
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 87
IP  - 9
DP  - 2009 May 15
TI  - Effects of blood transfusions given after renal transplantation.
PG  - 1381-6
LID - 10.1097/TP.0b013e3181a24b96 [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) antibodies produced after 
      transplantation are frequently measured in transplant recipients, because they 
      are strongly associated with humoral rejection and graft loss. However, 
      antibodies can be induced by posttransplant blood transfusions rather than by the 
      graft, casting doubts about the possible role of antibodies in a patient with 
      graft dysfunction. METHODS: We recorded the posttransplant transfusions in 746 
      patients transplanted during a 6-year period. Rejection episodes were evaluated 
      after exclusion of patients who were transfused proximate to the time of 
      rejection. Specimens for solid-phase HLA antibody testing were available in 199 
      patients. RESULTS: The frequency of transfusions was 45%, but it was higher in 
      deceased donor transplants (51%) than in live donor transplants (30%). Almost 80% 
      of the transfusions were given during the first month after transplant. However, 
      the incidence of posttransplant antibodies was similar in patients transfused and 
      not transfused, and only 1 of 12 patients who received more than 10 transfusions 
      produced antibodies. There was no evidence that posttransplant antibodies not 
      directed to donor antigens were triggered by transfusions. The incidence of 
      rejection episodes, allograft nephropathy, and graft loss was slightly more in 
      transfused patients but the differences were not statistically significant. 
      CONCLUSIONS: When HLA antibodies are detected posttransplant, they are likely 
      induced by the graft rather than by any transfusions the patient may have 
      received. The results suggest that posttransplant transfusions do not have the 
      sensitizing or down-regulatory effects of pretransplant transfusions.
FAU - Scornik, Juan C
AU  - Scornik JC
AD  - Department of Pathology, University of Florida College of Medicine, Gainesville, 
      FL 32610, USA. scornik@ufl.edu
FAU - Schold, Jesse D
AU  - Schold JD
FAU - Bucci, Michael
AU  - Bucci M
FAU - Meier-Kriesche, Herwig-Ulf
AU  - Meier-Kriesche HU
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - Adult
MH  - *Blood Transfusion/statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Isoantibodies/*blood
MH  - Kidney Transplantation/immunology/*physiology
MH  - Male
MH  - Middle Aged
MH  - Pancreas Transplantation/immunology/physiology
EDAT- 2009/05/09 09:00
MHDA- 2009/07/09 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/07/09 09:00 [medline]
AID - 00007890-200905150-00019 [pii]
AID - 10.1097/TP.0b013e3181a24b96 [doi]
PST - ppublish
SO  - Transplantation. 2009 May 15;87(9):1381-6. doi: 10.1097/TP.0b013e3181a24b96.