PMID- 19424053
OWN - NLM
STAT- MEDLINE
DCOM- 20091214
LR  - 20221207
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 23
IP  - 11
DP  - 2009 Jul 17
TI  - Severe aseptic leucoencephalopathy as immune reconstitution inflammatory syndrome 
      in Caucasian and African patients.
PG  - 1435-7
LID - 10.1097/QAD.0b013e32832c4101 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) after HAART may become 
      manifest in form of aseptic severe leucoencephalopathy. All HIV-1-positive 
      patients in this case series had widespread laboratory tests and follow-up MRI in 
      order to investigate the course and the underlying pathophysiology of 
      IRIS-associated leucoencephalopathy. All patients were treated with 
      corticosteroids, in spite of additional immunosuppression. Three patients were 
      successfully treated with corticosteroids and survived up to now, one died. A 
      neuropathological examination was performed showing massive aseptic 
      intraparenchymal and perivascular invasion of cytotoxic CD8 cells. It is assumed 
      that IRIS-associated leucoencephalopathy is based on other preconditions in 
      Africans and Caucasians.
FAU - Ringelstein, Adrian
AU  - Ringelstein A
AD  - Department of Neurology, Heinrich Heine University, Duesseldorf, Germany. 
      a.ringelstein@gmx.de
FAU - Oelschlaeger, Christian
AU  - Oelschlaeger C
FAU - Saleh, Andreas
AU  - Saleh A
FAU - Mathys, Christian
AU  - Mathys C
FAU - Dziewas, Rainer
AU  - Dziewas R
FAU - Niederstadt, Thomas
AU  - Niederstadt T
FAU - Reichelt, Doris
AU  - Reichelt D
FAU - Hasselblatt, Martin
AU  - Hasselblatt M
FAU - Husstedt, Ingo W
AU  - Husstedt IW
FAU - Arendt, Gabriele
AU  - Arendt G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adult
MH  - Anti-HIV Agents/therapeutic use
MH  - Antiretroviral Therapy, Highly Active
MH  - Black People
MH  - Fatal Outcome
MH  - Female
MH  - HIV Infections/drug therapy/immunology/*virology
MH  - *HIV-1
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/immunology/*virology
MH  - Leukoencephalopathy, Progressive Multifocal/immunology/*virology
MH  - Male
MH  - Middle Aged
MH  - White People
EDAT- 2009/05/09 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.1097/QAD.0b013e32832c4101 [doi]
PST - ppublish
SO  - AIDS. 2009 Jul 17;23(11):1435-7. doi: 10.1097/QAD.0b013e32832c4101.