PMID- 19424097
OWN - NLM
STAT- MEDLINE
DCOM- 20090821
LR  - 20201209
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 20
IP  - 9
DP  - 2009 Jun 17
TI  - Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat 
      cortical cell culture.
PG  - 828-32
LID - 10.1097/WNR.0b013e32832b7324 [doi]
AB  - In this study, possible involvements of choline and nicotinic acetylcholine 
      receptors (nAChRs) in neurotrophic-related neuronal plasticity were investigated. 
      Primary cell cultures from rat cerebral cortex were exposed for 72 h to the 
      alpha7 nAChR selective agonist choline and protein expression levels of the 
      neurotrophin receptors p75, TrkA, TrkB and TrkC were examined. The results 
      revealed a choline-induced attenuation of the TrkB expression, whereas the other 
      neurotrophin receptors were not affected. Further analysis of choline-exposed 
      cell cultures showed an increased protein level of the TrkB ligand brain-derived 
      neurotrophic factor (BDNF). This increase was obtained in cell cultures where the 
      alpha7 nAChR subunit was detected, but not in younger cell cultures where this 
      subunit could not be detected. It is speculated that a choline-induced change of 
      alpha7 nAChRs activity may have resulted in the observed increase of BDNF level 
      and down-regulation of the TrkB receptor.
FAU - Johansson, Jan
AU  - Johansson J
AD  - Department of Medicine and Public Health, Section of Pharmacology, University of 
      Verona, Piazzale L. Scuro, Verona, Italy.
FAU - Formaggio, Elena
AU  - Formaggio E
FAU - Fumagalli, Guido
AU  - Fumagalli G
FAU - Chiamulera, Christian
AU  - Chiamulera C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Chrna7 protein, rat)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nicotinic Agonists)
RN  - 0 (Receptors, Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Receptors, Nicotinic)
RN  - 0 (alpha7 Nicotinic Acetylcholine Receptor)
RN  - 136958-07-1 (Ngfr protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology/*metabolism
MH  - Choline/*metabolism/pharmacology
MH  - Down-Regulation/physiology
MH  - Nerve Tissue Proteins
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Nicotinic Agonists/metabolism/pharmacology
MH  - Rats
MH  - Receptor, trkA/drug effects/metabolism
MH  - Receptor, trkB/*metabolism
MH  - Receptors, Growth Factor
MH  - Receptors, Nerve Growth Factor/drug effects/metabolism
MH  - Receptors, Nicotinic/drug effects/*metabolism
MH  - Signal Transduction/drug effects/physiology
MH  - Up-Regulation/physiology
MH  - alpha7 Nicotinic Acetylcholine Receptor
EDAT- 2009/05/09 09:00
MHDA- 2009/08/22 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/08/22 09:00 [medline]
AID - 10.1097/WNR.0b013e32832b7324 [doi]
PST - ppublish
SO  - Neuroreport. 2009 Jun 17;20(9):828-32. doi: 10.1097/WNR.0b013e32832b7324.