PMID- 19424554
OWN - NLM
STAT- MEDLINE
DCOM- 20090825
LR  - 20090508
IS  - 1995-9133 (Electronic)
IS  - 1684-1182 (Linking)
VI  - 42
IP  - 1
DP  - 2009 Feb
TI  - Predicted epitopes of malarial merozoite surface protein 1 by bioinformatics 
      method: a clue for further vaccine development.
PG  - 19-21
AB  - BACKGROUND AND PURPOSE: Malarial merozoite surface protein 1 (MSP-1) may have 
      value as a protective immunogen in novel vaccines against malaria. This study was 
      performed to find potential T-cell epitopes for MSP-1 of Plasmodium vivax. 
      METHODS: Computation analysis of available MSP-1 of the P. vivax malaria sequence 
      was performed to find potential T-cell epitopes using MHCPred version 2.0. 
      Alleles for binding affinity prediction were selected and the peptides with the 
      best binding affinities for each allele were investigated. RESULTS: The peptides 
      with the best predicted binding affinities were human leukocyte antigen 
      (HLA)-DRB0101, HLA-A0203, and HLA-DRB0701, which showed significantly lower 50% 
      inhibitory concentration values than the other alleles. CONCLUSION: These data 
      are useful for further vaccine development because the promiscuous peptide 
      binders enable reduction of the number of predicted epitopes without compromising 
      the population coverage required for vaccine design.
FAU - Wiwanitkit, Viroj
AU  - Wiwanitkit V
AD  - Department of Clinical Laboratory Medicine, Faculty of Medicine, Wiwanitkit 
      House, Bangkok, Thailand. wviroj@yahoo.com
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-A Antigens)
RN  - 0 (Merozoite Surface Protein 1)
SB  - IM
MH  - Animals
MH  - Computational Biology/*methods
MH  - Epitopes, T-Lymphocyte/*genetics/metabolism
MH  - HLA-A Antigens/*genetics/metabolism
MH  - Humans
MH  - Merozoite Surface Protein 1/*genetics/metabolism
MH  - Models, Biological
MH  - Plasmodium vivax/*genetics
MH  - Protein Binding/genetics
EDAT- 2009/05/09 09:00
MHDA- 2009/08/26 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/08/26 09:00 [medline]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2009 Feb;42(1):19-21.