PMID- 19424612
OWN - NLM
STAT- MEDLINE
DCOM- 20090709
LR  - 20190606
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 21
IP  - 6
DP  - 2009 Jun
TI  - Immunohistochemical profile of neurotrophins in human cranial dura mater and 
      meningiomas.
PG  - 1373-80
AB  - The immunohistochemical profile of neurotrophins and their receptors in the human 
      cranial dura mater was studied by examining certain dural zones in specimens 
      harvested from different regions (frontal, temporal, parietal and occipital). 
      Dural specimens were obtained during neurosurgical operations performed in ten 
      patients for surgical treatment of intracranial lesions (meningiomas, traumas, 
      gliomas, vascular malformations). The dural fragments were taken from the area of 
      the craniotomy at least 8 cm from the lesion as well as from the area in which 
      the meningioma had its dural attachment. Immunohistochemical characterization and 
      distribution of neurotrophins, with their receptors, were analyzed. The concrete 
      role played by these neurotrophic factors in general regulation, vascular 
      permeability, algic responsivity and release of locally active substances in the 
      human dura mater is still controversial. Our study revealed a general structural 
      alteration of dural tissue due to the invasivity of meningiomatous lesions, 
      together with an improved expression of brain derived neurotrophic factor (BDNF) 
      in highly proliferating neoplastic cells and an evident production of nerve 
      growth factor (NGF) in inflammatory cells, suggesting that BDNF has a role in 
      supporting the proliferation rate of neoplastic cells, while NGF is involved in 
      the activation of a chronic inflammatory response in neoplastic areas.
FAU - Artico, Marco
AU  - Artico M
AD  - Department of Otorhinolaringology, Audiology and Phoniatry 'G. Ferreri', 
      University of Rome 'La Sapienza', 00161 Rome, Italy. marco.artico@uniroma1.it
FAU - Bronzetti, Elena
AU  - Bronzetti E
FAU - Pompili, Elena
AU  - Pompili E
FAU - Ionta, Brunella
AU  - Ionta B
FAU - Alicino, Valentina
AU  - Alicino V
FAU - D'Ambrosio, Anna
AU  - D'Ambrosio A
FAU - Santoro, Antonio
AU  - Santoro A
FAU - Pastore, Francesco S
AU  - Pastore FS
FAU - Elenkov, Ilia
AU  - Elenkov I
FAU - Fumagalli, Lorenzo
AU  - Fumagalli L
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Craniotomy
MH  - Dura Mater/*chemistry/pathology/surgery
MH  - Humans
MH  - *Immunohistochemistry
MH  - Meningeal Neoplasms/*chemistry/genetics/pathology/surgery
MH  - Meningioma/*chemistry/genetics/pathology/surgery
MH  - Middle Aged
MH  - Nerve Growth Factor/analysis
MH  - Nerve Growth Factors/*analysis/genetics
MH  - RNA, Messenger/analysis
MH  - Receptors, Nerve Growth Factor/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2009/05/09 09:00
MHDA- 2009/07/10 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/07/10 09:00 [medline]
AID - 10.3892/or_00000363 [doi]
PST - ppublish
SO  - Oncol Rep. 2009 Jun;21(6):1373-80. doi: 10.3892/or_00000363.