PMID- 19424630
OWN - NLM
STAT- MEDLINE
DCOM- 20090709
LR  - 20221011
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 21
IP  - 6
DP  - 2009 Jun
TI  - Increased expression of telomere-related proteins correlates with resistance to 
      radiation in human laryngeal cancer cell lines.
PG  - 1505-9
AB  - Telomere-associated proteins function as survival factors in telomere 
      maintenance, which are major contributors to radiosensitivity in human cancers. 
      The aim of this study was to investigate the association of telomere-associated 
      gene expression and radiation resistance in human larynx squamous carcinoma. The 
      changes of telomere-associated gene expressions and bionomical characteristics 
      that occur in two human larynx squamous carcinoma cell lines (Hep-2 and Hep-2R), 
      with different radiosensitivities in vitro were explored in the present study. 
      Based on previous research, elevated POT1 and TPP1 expressions were detected by 
      reverse transcription-PCR and Western blotting in Hep-2R cell lines. Furthermore, 
      Hep-2R cells showed increased recovery ratio accompanied by a reduction of cell 
      arrested in G2/S phase, suggesting that the radioresistance of Hep-2R cells was 
      due to a faster growth in which telomere length had recently been demonstrated to 
      be a powerful prognostic marker. These results manifest that radioresistant 
      Hep-2R cell lines showed certain changes in gene expression and bionomical 
      profiles that are different from the profile changes of the more-sensitive Hep-2 
      cell lines, and that evaluation of telomere-associated genes may be a prognostic 
      marker for response to radiotherapy in larynx squamous cell carcinoma (LSCC).
FAU - Tang, Tian
AU  - Tang T
AD  - Department of Radio-Chemotherapy, Zhongnan Hospital, Wuhan University, Wuhan 
      430071, P.R. China.
FAU - Zhou, Fu-Xiang
AU  - Zhou FX
FAU - Lei, Han
AU  - Lei H
FAU - Yu, Hai-Jun
AU  - Yu HJ
FAU - Xie, Cong-Hua
AU  - Xie CH
FAU - Zhou, Yun-Feng
AU  - Zhou YF
FAU - Liu, Shi-Quan
AU  - Liu SQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (ACD protein, human)
RN  - 0 (POT1 protein, human)
RN  - 0 (Shelterin Complex)
RN  - 0 (Telomere-Binding Proteins)
SB  - IM
MH  - Blotting, Western
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology
MH  - Cell Cycle/radiation effects
MH  - Cell Line, Tumor
MH  - Cell Proliferation/radiation effects
MH  - Cell Survival/radiation effects
MH  - Dose-Response Relationship, Radiation
MH  - Gene Expression Regulation, Neoplastic/radiation effects
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - *Radiation Tolerance
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Shelterin Complex
MH  - Telomere-Binding Proteins/genetics/metabolism/*radiation effects
MH  - Up-Regulation
EDAT- 2009/05/09 09:00
MHDA- 2009/07/10 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/07/10 09:00 [medline]
AID - 10.3892/or_00000381 [doi]
PST - ppublish
SO  - Oncol Rep. 2009 Jun;21(6):1505-9. doi: 10.3892/or_00000381.