PMID- 19424638
OWN - NLM
STAT- MEDLINE
DCOM- 20090709
LR  - 20190606
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 21
IP  - 6
DP  - 2009 Jun
TI  - Concentrations of organohalogen compounds and titres of antibodies to 
      Epstein-Barr virus antigens and the risk for non-Hodgkin lymphoma.
PG  - 1567-76
AB  - Exposure to some pesticides and persistent organic pollutants (POPs) has been 
      indicated to be a risk factor for non-Hodgkin's lymphoma (NHL). Epstein-Barr 
      virus (EBV) has been associated with some subgroups of NHL. In a previous study 
      we found an interaction between high concentrations of some POPs and titres of 
      antibodies to EBV early antigen (EA IgG) in relation to NHL. In the present study 
      we measured lipid adjusted plasma concentrations of 35 congeners of 
      polychlorinated biphenyls (PCB), p,p'-dichlorodiphenyldichloroethyelene 
      (p,p'-DDE), hexachlorobenzene (HCB), seven subgroups of chlordanes 
      (cis-heptachlorepoxide, cis-chlordane, trans-chlordane, oxychlordane, MC6, 
      trans-nonachlordane, cis-nonachlordane) and one polybrominated diphenylether 
      (PBDE) congener (no. 47) in 99 cases with NHL and 99 population based controls. 
      Odds ratios (OR) for NHL were estimated. Sum of PCBs > median in the controls 
      gave odds ratio (OR) 2.0, 95% confidence interval (CI) 0.99-3.9. High sum of 
      chlordanes yielded OR 2.3, 95% CI 1.2-4.5. An interaction with EBV EA IgG was 
      found. High sum of PCB gave OR 5.2, 95% CI 1.9-14 in the group with EA IgG > 40. 
      Similarly HCB yielded OR 5.3, 95% CI 1.9-15, pp'-DDE gave OR 3.3, 95% CI 1.4-7.7 
      and sum of chlordanes yielded OR 6.8, 95% CI 2.3-20, whereas no association was 
      found with PBDE. In summary, this study confirmed an association between certain 
      POPs and NHL with an interaction with titre of IgG antibody to EBV EA.
FAU - Hardell, Karin
AU  - Hardell K
AD  - MTM Research Centre, School of Science and Technology, Orebro University, SE-701 
      82 Orebro, Sweden.
FAU - Carlberg, Michael
AU  - Carlberg M
FAU - Hardell, Lennart
AU  - Hardell L
FAU - Bjornfoth, Helen
AU  - Bjornfoth H
FAU - Ericson Jogsten, Ingrid
AU  - Ericson Jogsten I
FAU - Eriksson, Mikael
AU  - Eriksson M
FAU - Van Bavel, Bert
AU  - Van Bavel B
FAU - Lindstrom, Gunilla
AU  - Lindstrom G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Capsid Proteins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Epstein-Barr viral capsid antigen)
RN  - 0 (Epstein-Barr virus early antigen)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/*blood
MH  - Antigens, Viral/immunology
MH  - Capsid Proteins/immunology
MH  - Case-Control Studies
MH  - Environmental Pollutants/adverse effects/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/adverse effects/*blood
MH  - Herpesvirus 4, Human/*immunology
MH  - Humans
MH  - Hydrocarbons, Chlorinated/adverse effects/*blood
MH  - Immunoglobulin G/*blood
MH  - Logistic Models
MH  - Lymphoma, Non-Hodgkin/chemically induced/*etiology/virology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Population Surveillance
MH  - Risk Assessment
MH  - Risk Factors
MH  - Young Adult
EDAT- 2009/05/09 09:00
MHDA- 2009/07/10 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/07/10 09:00 [medline]
AID - 10.3892/or_00000389 [doi]
PST - ppublish
SO  - Oncol Rep. 2009 Jun;21(6):1567-76. doi: 10.3892/or_00000389.