PMID- 19424778
OWN - NLM
STAT- MEDLINE
DCOM- 20100114
LR  - 20211020
IS  - 1573-4838 (Electronic)
IS  - 0957-4530 (Linking)
VI  - 20
IP  - 10
DP  - 2009 Oct
TI  - Low temperature fabrication of high strength porous calcium phosphate and the 
      evaluation of the osteoconductivity.
PG  - 2025-34
LID - 10.1007/s10856-009-3764-7 [doi]
AB  - Porous NaO(2)-MgO-CaO-P(2)O(5) bioglass doped beta-tri-calcium phosphate 
      (beta-TCP) bioceramic possessing high mechanical properties and well pore 
      structure with high porosity and high pore connectivity has been prepared through 
      dipping method with the porous polyurethane as the pore forming template. The 
      sintering mechanism and the mechanical properties of the bioglass doped beta-TCP 
      scaffold have been investigated by the X-ray diffraction (XRD) analysis, Scanning 
      electron microscope (SEM) and thermal differential analysis (DTA). The scaffold's 
      in vivo osteoconductivity has been evaluated by implantation of scaffolds into 
      the femurs of New Zealand rabbits. The results show that the porous structure can 
      achieve the densification process at a low temperature about 950 degrees C by a 
      solid solution sintering mechanism and hence dense macropore scaffold with a 
      compressive strength of 4.32 MPa when the porosity is 75% has been obtained. The 
      in vivo test shows that the Na(2)O-MgO-CaO-P(2)O(5) bioglass doped porous 
      beta-TCP bioceramic has a relatively fast bone formation after implantation; 
      after 1 month implantation new deposited bone tissue has been detected on the 
      strut of the porous scaffold and degraded particles also has been found on the 
      surface of the new formed bone. After 6 months implantation the porous scaffold 
      has been thoroughly covered with new formed bone. Results show that the 
      Na(2)O-MgO-CaO-P(2)O(5) bioglass doped porous beta-TCP bioceramic is potential 
      bone tissue engineering scaffold for orthopedic use.
FAU - Yu, Xianzhu
AU  - Yu X
AD  - Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of 
      Education, Tianjin University, Tianjin 300072, People's Republic of China.
FAU - Cai, Shu
AU  - Cai S
FAU - Xu, Guohua
AU  - Xu G
FAU - Zhou, Wei
AU  - Zhou W
FAU - Wang, Dongmei
AU  - Wang D
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090508
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 97Z1WI3NDX (calcium phosphate)
SB  - IM
MH  - Animals
MH  - Bone Regeneration/*drug effects
MH  - Bone Substitutes/chemical synthesis/chemistry
MH  - Calcium Phosphates/*chemical synthesis/chemistry/*pharmacology
MH  - Chemistry, Inorganic/*methods
MH  - *Cold Temperature
MH  - Compressive Strength/*physiology
MH  - Male
MH  - Materials Testing
MH  - Osseointegration/drug effects
MH  - Porosity
MH  - Rabbits
MH  - Tissue Scaffolds/chemistry
MH  - X-Ray Diffraction
EDAT- 2009/05/09 09:00
MHDA- 2010/01/15 06:00
CRDT- 2009/05/09 09:00
PHST- 2008/10/19 00:00 [received]
PHST- 2009/04/24 00:00 [accepted]
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2010/01/15 06:00 [medline]
AID - 10.1007/s10856-009-3764-7 [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2009 Oct;20(10):2025-34. doi: 10.1007/s10856-009-3764-7. 
      Epub 2009 May 8.