PMID- 19424874
OWN - NLM
STAT- MEDLINE
DCOM- 20090817
LR  - 20221207
IS  - 0895-8696 (Print)
IS  - 0895-8696 (Linking)
VI  - 38
IP  - 3
DP  - 2009 Jul
TI  - Effect of BDNF Val66Met polymorphism on digital working memory and spatial 
      localization in a healthy Chinese Han population.
PG  - 250-6
LID - 10.1007/s12031-009-9205-8 [doi]
AB  - Cognitive abilities are complex human traits influenced by genetic factors. 
      Brain-derived neurotrophic factor (BDNF), a unique polypeptide growth factor, has 
      an influence on the differentiation and survival of neurons in the nervous 
      system. A single-nucleotide polymorphism (rs6265) in the human gene, resulting in 
      a valine to methionine substitution in the pro-BDNF protein, was thought to 
      associate with psychiatric disorders and might play roles in the individual 
      difference of cognitive abilities. However, the specific roles of the gene in 
      cognition remain unclear. To investigate the relationships between the 
      substitution and cognitive abilities, a healthy population-based study and the 
      PCR-SSCP method were performed. The results showed the substitution was 
      associated with digital working memory (p = 0.02) and spatial localization (p = 
      0.03), but not with inhibition, shifting, updating, visuo-spatial working memory, 
      long-term memory, and others (p > 0.05) among the compared genotype groups 
      analyzed by general linear model. On the other hand, the participants with BDNF 
      (GG) had higher average performance in digital working memory and spatial 
      localization than the ones with BDNF (AA). The findings of the present work 
      implied that the variation in BDNF might play positive roles in human digital 
      working memory and spatial localization.
FAU - Gong, Pingyuan
AU  - Gong P
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry 
      of Education), Institute of Population & Health, College of Life Science, 
      Northwest University, Xi'an, China.
FAU - Zheng, Anyun
AU  - Zheng A
FAU - Chen, Dongmei
AU  - Chen D
FAU - Ge, Wanhua
AU  - Ge W
FAU - Lv, Changchao
AU  - Lv C
FAU - Zhang, Kejin
AU  - Zhang K
FAU - Gao, Xiaocai
AU  - Gao X
FAU - Zhang, Fuchang
AU  - Zhang F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090508
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Asian People/*genetics
MH  - *Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cognition/physiology
MH  - Ethnicity/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Methionine/genetics
MH  - Neuropsychological Tests
MH  - *Polymorphism, Single Nucleotide
MH  - Spatial Behavior/*physiology
MH  - Valine/genetics
MH  - Young Adult
EDAT- 2009/05/09 09:00
MHDA- 2009/08/18 09:00
CRDT- 2009/05/09 09:00
PHST- 2009/03/03 00:00 [received]
PHST- 2009/04/13 00:00 [accepted]
PHST- 2009/05/09 09:00 [entrez]
PHST- 2009/05/09 09:00 [pubmed]
PHST- 2009/08/18 09:00 [medline]
AID - 10.1007/s12031-009-9205-8 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2009 Jul;38(3):250-6. doi: 10.1007/s12031-009-9205-8. Epub 2009 
      May 8.