PMID- 19426822
OWN - NLM
STAT- MEDLINE
DCOM- 20090928
LR  - 20161125
IS  - 1095-8355 (Electronic)
IS  - 1065-6995 (Linking)
VI  - 33
IP  - 7
DP  - 2009 Jul
TI  - Modifications of erythrocyte membrane hydration induced by organic tin compounds.
PG  - 801-6
LID - 10.1016/j.cellbi.2009.04.016 [doi]
AB  - A study on the effects of selected organic chlorides of tin on the extent of 
      hydration of the lipid bilayer of erythrocyte ghosts from pig blood is presented. 
      The following compounds were used, dibutyltin dichloride (DBT), tributyltin 
      chloride (TBT), diphenyltin dichloride (DPhT) and triphenyltin chloride (TPhT). 
      The degree of membrane hydration was measured by the ATR FTIR technique, which 
      makes it possible to estimate the level of carbonyl and phosphate group hydration 
      in lipids of membranes. Other measurements were made with a fluorescence 
      technique involving a laurdan probe. Tin organic compounds caused dehydration of 
      the lipid bilayer of ghosts in the region of the carbonyl groups. DBT and TBT 
      produced weak dehydration in the region of the phosphate group, whereas DPhT and 
      TPhT increased hydration. The results allow one to determine the location of 
      organotin compounds within a membrane, and show that TBT penetrates the membrane 
      the deepest and DBT the shallowest. Phenyl tin compounds penetrate membranes to 
      an intermediate depth. The results obtained indicate that the destructive 
      properties of the organometallic compounds depend mostly on their effect on 
      hydration of the membrane.
FAU - Zylka, Romuald
AU  - Zylka R
AD  - Department of Physics and Biophysics, Wroclaw University of Environmental and 
      Life Sciences, Wroclaw, Poland. roumald.zylka@up.wroc.pl
FAU - Kleszczynska, Halina
AU  - Kleszczynska H
FAU - Kupiec, Justyna
AU  - Kupiec J
FAU - Bonarska-Kujawa, Dorota
AU  - Bonarska-Kujawa D
FAU - Hladyszowski, Jerzy
AU  - Hladyszowski J
FAU - Przestalski, Stanislaw
AU  - Przestalski S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090506
PL  - England
TA  - Cell Biol Int
JT  - Cell biology international
JID - 9307129
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Organotin Compounds)
RN  - 0 (Trialkyltin Compounds)
RN  - 1011-95-6 (diphenyltin)
RN  - 4XDX163P3D (tributyltin)
RN  - I1L80IDY27 (triphenyltin chloride)
RN  - J4AQN88R8P (dibutyldichlorotin)
SB  - IM
MH  - Animals
MH  - Dehydration
MH  - Erythrocyte Membrane/*drug effects
MH  - Fluorescent Dyes/chemistry
MH  - Organotin Compounds/*pharmacology
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Swine
MH  - Trialkyltin Compounds/pharmacology
EDAT- 2009/05/12 09:00
MHDA- 2009/09/29 06:00
CRDT- 2009/05/12 09:00
PHST- 2008/12/22 00:00 [received]
PHST- 2009/03/06 00:00 [revised]
PHST- 2009/04/24 00:00 [accepted]
PHST- 2009/05/12 09:00 [entrez]
PHST- 2009/05/12 09:00 [pubmed]
PHST- 2009/09/29 06:00 [medline]
AID - S1065-6995(09)00108-5 [pii]
AID - 10.1016/j.cellbi.2009.04.016 [doi]
PST - ppublish
SO  - Cell Biol Int. 2009 Jul;33(7):801-6. doi: 10.1016/j.cellbi.2009.04.016. Epub 2009 
      May 6.