PMID- 19427892
OWN - NLM
STAT- MEDLINE
DCOM- 20091013
LR  - 20131121
IS  - 1638-6183 (Electronic)
IS  - 0300-9084 (Linking)
VI  - 91
IP  - 8
DP  - 2009 Aug
TI  - Metabolic phenotyping of genetically modified mice: An NMR metabonomic approach.
PG  - 1053-7
LID - 10.1016/j.biochi.2009.04.019 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) plays a relevant role in macrophage 
      migration but recent findings suggest an additional role in lipid and glucose 
      metabolism. We report the use of (1)H NMR spectroscopy as a useful complementary 
      method to assess the metabolic function of this gene in a comparative strategy. 
      This metabonomic analysis was rapid, simple, quantitative and reproducible, and 
      revealed a suggestive relationship between the expression of the MCP-1 gene and 
      hepatic glucose and taurine concentrations. This approach should be considered in 
      genetically modified mice when a metabolic alteration is suspected, or in routine 
      assessment of metabolic phenotype.
FAU - Rull, Anna
AU  - Rull A
AD  - Centre de Recerca Biomedica, Hospital Universitari Sant Joan de Reus, IISPV, 
      Universitat Rovira i Virgili, Spain.
FAU - Vinaixa, Maria
AU  - Vinaixa M
FAU - Angel Rodriguez, Miguel
AU  - Angel Rodriguez M
FAU - Beltran, Raul
AU  - Beltran R
FAU - Brezmes, Jesus
AU  - Brezmes J
FAU - Canellas, Nicolau
AU  - Canellas N
FAU - Correig, Xavier
AU  - Correig X
FAU - Joven, Jorge
AU  - Joven J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090509
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - Liver/chemistry/cytology/metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Metabolomics/*methods
MH  - Mice/*genetics/*metabolism
MH  - Mice, Transgenic
MH  - Molecular Weight
MH  - *Phenotype
MH  - Water/chemistry
EDAT- 2009/05/12 09:00
MHDA- 2009/10/14 06:00
CRDT- 2009/05/12 09:00
PHST- 2008/12/29 00:00 [received]
PHST- 2009/04/27 00:00 [accepted]
PHST- 2009/05/12 09:00 [entrez]
PHST- 2009/05/12 09:00 [pubmed]
PHST- 2009/10/14 06:00 [medline]
AID - S0300-9084(09)00125-4 [pii]
AID - 10.1016/j.biochi.2009.04.019 [doi]
PST - ppublish
SO  - Biochimie. 2009 Aug;91(8):1053-7. doi: 10.1016/j.biochi.2009.04.019. Epub 2009 
      May 9.