PMID- 19428650 OWN - NLM STAT- MEDLINE DCOM- 20090630 LR - 20090511 IS - 1872-7549 (Electronic) IS - 0166-4328 (Linking) VI - 201 IP - 2 DP - 2009 Aug 12 TI - Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus. PG - 311-7 LID - 10.1016/j.bbr.2009.03.002 [doi] AB - Memory impairment is considered to be one of the most prominent consequences of aging. Deterioration of memory begins in advance of old age in animals, including humans. Thus, it is extremely important to prevent memory decline for increasing healthy aging. Ginsenoside, the effective ingredient of ginseng, has been reported to have a neuron beneficial effect, but the preventive role on memory impairment and the underlying mechanisms have not been well determined. In the present study, C57BL/6J mice aged 12 months were chronically treated with ginsenoside 100mg/kg per day for 8 months. Placebo-treated aged mice, young and adult ones (4- and 8-month-old, respectively) were used as controls. The efficacious effect of ginsenoside was manifested in the amelioration of memory impairment in aged mice by Morris water maze and step-down tests. Compared with aged control group, the plasticity-related proteins including phospho-N-methyl-d-aspartate receptor1 (NMDAR1), phospho-calcium-calmodulin dependent kinase II (CaMK II), phospho-PKA catalytic beta subunit (PKA Cbeta), phospho-cAMP-response element binding protein (CREB) and brain derived neurotrophic factor (BDNF) in hippocampus significantly increased in ginsenoside treated group. These findings suggest that ginsenoside is effective on the prevention of age-related memory impairment, and the up-regulation of plasticity-related proteins in hippocampus may be one of the mechanisms. FAU - Zhao, Haifeng AU - Zhao H AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Xueyuan Road 38, Beijing 100191, PR China. FAU - Li, Qiong AU - Li Q FAU - Pei, Xinrong AU - Pei X FAU - Zhang, Zhaofeng AU - Zhang Z FAU - Yang, Ruiyue AU - Yang R FAU - Wang, Junbo AU - Wang J FAU - Li, Yong AU - Li Y LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090317 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Cyclic AMP Response Element-Binding Protein) RN - 0 (Ginsenosides) RN - 0 (NMDA receptor A1) RN - 0 (Nerve Tissue Proteins) RN - 0 (Nootropic Agents) RN - 0 (Receptors, N-Methyl-D-Aspartate) RN - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinase Catalytic Subunits) RN - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2) SB - IM MH - Aging/*physiology MH - Analysis of Variance MH - Animals MH - Avoidance Learning/drug effects/physiology MH - Brain-Derived Neurotrophic Factor/drug effects/metabolism MH - Calcium-Calmodulin-Dependent Protein Kinase Type 2/drug effects/metabolism MH - Cyclic AMP Response Element-Binding Protein/drug effects/metabolism MH - Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/drug effects/metabolism MH - Female MH - Ginsenosides/*administration & dosage MH - Hippocampus/drug effects/*enzymology MH - Maze Learning/*drug effects/physiology MH - Mice MH - Mice, Inbred C57BL MH - Nerve Tissue Proteins/drug effects/*metabolism MH - Neuronal Plasticity/drug effects/physiology MH - Nootropic Agents/*administration & dosage MH - Psychomotor Performance/drug effects/physiology MH - Reaction Time/drug effects/physiology MH - Receptors, N-Methyl-D-Aspartate/drug effects/metabolism MH - Time Factors EDAT- 2009/05/12 09:00 MHDA- 2009/07/01 09:00 CRDT- 2009/05/12 09:00 PHST- 2009/01/10 00:00 [received] PHST- 2009/02/27 00:00 [revised] PHST- 2009/03/04 00:00 [accepted] PHST- 2009/05/12 09:00 [entrez] PHST- 2009/05/12 09:00 [pubmed] PHST- 2009/07/01 09:00 [medline] AID - S0166-4328(09)00148-X [pii] AID - 10.1016/j.bbr.2009.03.002 [doi] PST - ppublish SO - Behav Brain Res. 2009 Aug 12;201(2):311-7. doi: 10.1016/j.bbr.2009.03.002. Epub 2009 Mar 17.