PMID- 19429034
OWN - NLM
STAT- MEDLINE
DCOM- 20090622
LR  - 20151119
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 453
IP  - 3
DP  - 2009 Apr 10
TI  - Serum brain-derived neurotrophic factor (BDNF) is not associated with response to 
      electroconvulsive therapy (ECT): a pilot study in drug resistant depressed 
      patients.
PG  - 195-8
LID - 10.1016/j.neulet.2009.02.032 [doi]
AB  - Refractory depression is a highly debilitating mental condition that originates 
      major social and economic burden. About 50% of the patients experience a chronic 
      course of illness and up to 20% show an insufficient response to drug treatments. 
      Electroconvulsive therapy (ECT) is the most effective treatment method in 
      refractory depression, although its mechanism of action is still unknown. 
      Brain-derived neurotrophic factor (BDNF) is decreased in depressive episodes, and 
      increases with antidepressant treatment, being suggested as a biomarker of 
      response to ECT. We report the findings of a study on the effects of ECT on BDNF 
      and clinical outcomes in a group of drug resistant depressive patients before and 
      after ECT. The patients post-ECTs have shown an important improvement of 
      depressive symptomatology on the HDRS (p=0.001), of psychotic features on the 
      BPRS (p=0.001) and of the severity of illness on the CGI (p=0.001). There were no 
      changes in the serum BDNF before and after the ECT treatment (p=0.89). These 
      results do not support the hypothesis that the clinical improvement following ECT 
      is due to changes in the BDNF.
FAU - Fernandes, Brisa
AU  - Fernandes B
AD  - Bipolar Disorder Program, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      Brazil.
FAU - Gama, Clarissa S
AU  - Gama CS
FAU - Massuda, Rafael
AU  - Massuda R
FAU - Torres, Mariana
AU  - Torres M
FAU - Camargo, Daniel
AU  - Camargo D
FAU - Kunz, Mauricio
AU  - Kunz M
FAU - Belmonte-de-Abreu, Paulo Silva
AU  - Belmonte-de-Abreu PS
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - de Almeida Fleck, Marcelo Pio
AU  - de Almeida Fleck MP
FAU - Ines Lobato, Maria
AU  - Ines Lobato M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090221
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Biomarkers/blood
MH  - Bipolar Disorder/blood/physiopathology/*therapy
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder/blood/physiopathology/*therapy
MH  - Drug Resistance
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Severity of Illness Index
EDAT- 2009/05/12 09:00
MHDA- 2009/06/23 09:00
CRDT- 2009/05/12 09:00
PHST- 2009/01/26 00:00 [received]
PHST- 2009/02/18 00:00 [revised]
PHST- 2009/02/18 00:00 [accepted]
PHST- 2009/05/12 09:00 [entrez]
PHST- 2009/05/12 09:00 [pubmed]
PHST- 2009/06/23 09:00 [medline]
AID - S0304-3940(09)00208-0 [pii]
AID - 10.1016/j.neulet.2009.02.032 [doi]
PST - ppublish
SO  - Neurosci Lett. 2009 Apr 10;453(3):195-8. doi: 10.1016/j.neulet.2009.02.032. Epub 
      2009 Feb 21.