PMID- 19429570
OWN - NLM
STAT- MEDLINE
DCOM- 20091201
LR  - 20221207
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 95
IP  - 16
DP  - 2009 Aug
TI  - Effects of exercise intervention on myocardial function in type 2 diabetes.
PG  - 1343-9
LID - 10.1136/hrt.2009.165571 [doi]
AB  - OBJECTIVE: To identify the effects of a 1-year exercise intervention on 
      myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM). DESIGN: 
      Randomised controlled trial, the Diabetes Lifestyle Intervention Study. SETTING: 
      University hospital. PATIENTS: 223 T2DM patients without occult coronary artery 
      disease, aged 18-75 were randomised to an exercise training group (n = 111) or a 
      usual care group (n = 112). Complete follow-up data were available in 176 (88 
      exercise, 88 usual care). INTERVENTIONS: Exercise training consisted of gym, 
      followed by telephone-monitored home-based exercise training. MAIN OUTCOME 
      MEASURES: Tissue Doppler-derived myocardial velocities, strain-rate and strain, 
      body composition, glycated haemoglobin (HbA(1c)), maximum oxygen consumption 
      (VO(2max)) and physical activity. RESULTS: Overall changes in myocardial function 
      were not different between groups despite improvements in waist circumference, 
      fat mass, blood glucose, HbA(1c), insulin sensitivity, VO(2max) and 6-minute walk 
      distance in the intervention group (p<0.05). The latter also spent significantly 
      more time in vigorous activity (p<0.05). A post-hoc analysis revealed that 
      intervention patients who spent more time in both moderate and vigorous activity 
      showed a significant improvement in myocardial tissue velocity (p<0.01), HbA(1c) 
      (p = 0.03) and VO(2max) (p = 0.03) compared to controls. Myocardial strain rate 
      (p = 0.03) and HbA(1c) improved in intervention patients with the greatest 
      increase in moderate activity (p = 0.03). CONCLUSIONS: In patients with T2DM, 
      current exercise recommendations led to an improvement in metabolic function, but 
      failed to improve myocardial function in the overall group. Patients with greater 
      increases in both moderate and vigorous activity showed improvements in 
      myocardial function, glycaemic control and cardiorespiratory fitness. TRIAL 
      REGISTRATION NUMBER: ACTRN12607000060448.
FAU - Hordern, M D
AU  - Hordern MD
AD  - School of Medicine, University of Queensland, Brisbane, Australia.
FAU - Coombes, J S
AU  - Coombes JS
FAU - Cooney, L M
AU  - Cooney LM
FAU - Jeffriess, L
AU  - Jeffriess L
FAU - Prins, J B
AU  - Prins JB
FAU - Marwick, T H
AU  - Marwick TH
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20090507
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Body Composition
MH  - Cardiomyopathies/diagnostic imaging/physiopathology/*therapy
MH  - Coronary Circulation
MH  - Diabetes Mellitus, Type 2/diagnostic imaging/physiopathology/*therapy
MH  - Diabetic Angiopathies/diagnostic imaging/physiopathology/*therapy
MH  - Echocardiography
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - Ultrasonography, Doppler
MH  - Young Adult
EDAT- 2009/05/12 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/05/12 09:00
PHST- 2009/05/12 09:00 [entrez]
PHST- 2009/05/12 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - hrt.2009.165571 [pii]
AID - 10.1136/hrt.2009.165571 [doi]
PST - ppublish
SO  - Heart. 2009 Aug;95(16):1343-9. doi: 10.1136/hrt.2009.165571. Epub 2009 May 7.