PMID- 19429670
OWN - NLM
STAT- MEDLINE
DCOM- 20090921
LR  - 20091119
IS  - 1479-6805 (Electronic)
IS  - 0022-0795 (Linking)
VI  - 202
IP  - 2
DP  - 2009 Aug
TI  - Angiotensin II enhances the increase in monocyte chemoattractant protein-1 
      production induced by tumor necrosis factor-alpha from 3T3-L1 preadipocytes.
PG  - 199-205
LID - 10.1677/JOE-08-0363 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) and angiotensin II (Ang II) in adipose 
      tissue are thought to induce systemic insulin resistance in rodents; but the 
      precise mechanism is not fully clarified. We examined the mechanism of Ang 
      II-induced and/or tumor necrosis factor-alpha (TNF-alpha)-induced MCP-1 
      production from 3T3-L1 preadipocytes. The MCP-1 protein and MCP-1 mRNA expression 
      in 3T3-L1 preadipocytes were increased significantly by stimulation with 
      TNF-alpha. We found no significant increase in MCP-1 concentrations by Ang II 
      alone; but it enhanced the TNF-alpha-induced MCP-1 mRNA expression in a 
      dose-dependent manner. Then, we examined the effect of Ang II and/or TNF-alpha on 
      phosphorylation of extracellular signal-regulated kinase (ERK), p38MAPK, and 
      IkappaB-alpha. Ang II and TNF-alpha clearly enhanced ERK and p38MAPK 
      phosphorylation. IkappaB-alpha phosphorylation was enhanced by TNF-alpha, but not 
      by Ang II. The MCP-1 mRNA expression induced by TNF-alpha and co-stimulation with 
      Ang II was inhibited by either ERK inhibitor, p38MAPK inhibitor or NF-kappaB 
      inhibitor. Moreover, Ang II enhanced the activation of AP-1 (c-fos) induced by 
      TNF-alpha. Our results suggest that Ang II may serve as an additional stimulus on 
      the TNF-alpha-induced MCP-1 production through the ERK-and p38MAPK-dependent 
      pathways probably due to AP-1 activation.
FAU - Asamizu, Sachie
AU  - Asamizu S
AD  - 1st Department of Medicine, Toyama University, Sugitani 2630, Toyama-shi 
      930-0194, Japan.
FAU - Urakaze, Masaharu
AU  - Urakaze M
FAU - Kobashi, Chikaaki
AU  - Kobashi C
FAU - Ishiki, Manabu
AU  - Ishiki M
FAU - Norel Din, Amal Khalifa
AU  - Norel Din AK
FAU - Fujisaka, Shiho
AU  - Fujisaka S
FAU - Kanatani, Yukiko
AU  - Kanatani Y
FAU - Bukahari, Agussalim
AU  - Bukahari A
FAU - Senda, Satoko
AU  - Senda S
FAU - Suzuki, Hikari
AU  - Suzuki H
FAU - Yamazaki, Yuh
AU  - Yamazaki Y
FAU - Iwata, Minoru
AU  - Iwata M
FAU - Usui, Isao
AU  - Usui I
FAU - Yamazaki, Katsuya
AU  - Yamazaki K
FAU - Ogawa, Hirofumi
AU  - Ogawa H
FAU - Kobayashi, Masashi
AU  - Kobayashi M
FAU - Tobe, Kazuyuki
AU  - Tobe K
LA  - eng
PT  - Journal Article
DEP - 20090508
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factor AP-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
SB  - IM
EIN - J Endocrinol. 2009 Oct;203(1):189. Ogawa, Hiroshi [corrected to Ogawa, Hirofumi]
MH  - 3T3-L1 Cells
MH  - Adipocytes/drug effects/*metabolism
MH  - Angiotensin II/*pharmacology
MH  - Animals
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Drug Synergism
MH  - Enzyme Activation/drug effects
MH  - Extracellular Signal-Regulated MAP Kinases
MH  - Mice
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Signal Transduction
MH  - Stem Cells/drug effects/*metabolism
MH  - Transcription Factor AP-1/metabolism
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - p38 Mitogen-Activated Protein Kinases/metabolism
EDAT- 2009/05/12 09:00
MHDA- 2009/09/22 06:00
CRDT- 2009/05/12 09:00
PHST- 2009/05/12 09:00 [entrez]
PHST- 2009/05/12 09:00 [pubmed]
PHST- 2009/09/22 06:00 [medline]
AID - JOE-08-0363 [pii]
AID - 10.1677/JOE-08-0363 [doi]
PST - ppublish
SO  - J Endocrinol. 2009 Aug;202(2):199-205. doi: 10.1677/JOE-08-0363. Epub 2009 May 8.