PMID- 19430383
OWN - NLM
STAT- MEDLINE
DCOM- 20090817
LR  - 20151119
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 65
IP  - 6
DP  - 2009 Jun
TI  - Relationship between adiponectin and ambulatory blood pressure in obese 
      adolescents.
PG  - 691-5
LID - 10.1203/PDR.0b013e31819ea776 [doi]
AB  - Obesity is associated with elevated blood pressure (BP), insulin resistance, and 
      altered plasma adiponectin levels; the relationship between the biochemical 
      features of obesity and 24-h ambulatory blood pressure (24-h ABP) parameters in 
      adolescents remains unknown. Anthropometric measurements and 24-h ABP monitoring 
      were obtained on 41 obese adolescents with and without type 2 diabetes mellitus 
      (T2DM). Serum adiponectin, high sensitivity C-reactive protein (hs-CRP), lipid 
      profile, insulin, fasting glucose, liver enzymes, Hb A1c (HbA1c), and two random 
      urine samples were obtained for creatinine and microalbumin measurements. The 
      determinants of 24-h systolic (SBP) and diastolic (DBP) BP were examined using 
      multivariate linear regression models with BP parameters as outcome variables. 
      Forty-one obese adolescents were studied. Adiponectin levels were reduced and 
      hs-CRP levels were elevated, and were inversely and significantly correlated (rho 
      = -0.3, p = 0.05). ABP showed blunted nocturnal SBP dipping. Twenty-four hour SBP 
      and DBP indexes were significantly (p < 0.05) and inversely correlated with 
      adiponectin (rho = -0.4 and -0.42), respectively. In multivariate models, lower 
      adiponectin level was independently associated with 24-h SBP and DBP. Adiponectin 
      inversely correlate with ABP parameters in obese adolescents. Larger studies are 
      needed to examine the relationship between adiponectin and mechanisms of BP 
      regulation.
FAU - Shatat, Ibrahim F
AU  - Shatat IF
AD  - Division of Pediatric Nephrology, The Medical University of South Carolina 
      Children's Hospital, Charleston, SC 29425, USA. Shatat@musc.edu
FAU - Freeman, Katherine D
AU  - Freeman KD
FAU - Vuguin, Patricia M
AU  - Vuguin PM
FAU - Dimartino-Nardi, Joan R
AU  - Dimartino-Nardi JR
FAU - Flynn, Joseph T
AU  - Flynn JT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adolescent
MH  - Anthropometry
MH  - Biomarkers/metabolism
MH  - Blood Pressure/*physiology
MH  - *Blood Pressure Monitoring, Ambulatory
MH  - Child
MH  - Diabetes Mellitus, Type 2/blood/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Obesity/blood/physiopathology
MH  - Young Adult
EDAT- 2009/05/12 09:00
MHDA- 2009/08/18 09:00
CRDT- 2009/05/12 09:00
PHST- 2009/05/12 09:00 [entrez]
PHST- 2009/05/12 09:00 [pubmed]
PHST- 2009/08/18 09:00 [medline]
AID - 10.1203/PDR.0b013e31819ea776 [doi]
PST - ppublish
SO  - Pediatr Res. 2009 Jun;65(6):691-5. doi: 10.1203/PDR.0b013e31819ea776.