PMID- 19434286
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1976-8710 (Print)
IS  - 2005-0720 (Electronic)
IS  - 1976-8710 (Linking)
VI  - 2
IP  - 1
DP  - 2009 Mar
TI  - Galectin-8 expression in laryngeal squamous cell carcinoma.
PG  - 13-9
LID - 10.3342/ceo.2009.2.1.13 [doi]
AB  - OBJECTIVES: Despite the ongoing development of treatment protocols for laryngeal 
      squamous cell carcinoma (LSCC), the patients suffering with this malady have 
      shown only a modestly improved outcome. This poor outcome has been attributed to 
      the lack of therapy that's individualized to the tumor's biological properties. 
      Various studies have showed that galectin-8 is widely expressed in tumor tissues 
      as well as in normal tissues, and the level of the galectin-8 expression may 
      correlate with the malignancy of human squamous cell carcinoma. The purpose of 
      this study is to evaluate the expression of galectin-8 and to investigate its 
      correlations with the primary stage, the nodal involvement, the clinical stage 
      and the histologic grade of squamous cell carcinoma of the larynx. METHODS: The 
      paraffin-embedded tissue specimens from 77 patients who were diagnosed as LSCC 
      between 1993 and 2007 were immunohistochemically stained for galectin-8. RESULTS: 
      Immunohistochemical analysis showed that a strong positive expression of 
      galectin-8 was correlated with the T-stages, the nodal stages and the clinical 
      stages. However, the histopathologic grades were not correlated with the 
      galectin-8 expression in LSCC. CONCLUSION: The expression of galectin-8 protein 
      can be used as a prognostic factor for patients with LSCC.
FAU - Dong, Geun Woo
AU  - Dong GW
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chosun University 
      College of Medicine, Gwangju, Korea.
FAU - Kim, Jun
AU  - Kim J
FAU - Park, Jun Hee
AU  - Park JH
FAU - Choi, Ji Yun
AU  - Choi JY
FAU - Cho, Sung Il
AU  - Cho SI
FAU - Lim, Sung Chul
AU  - Lim SC
LA  - eng
PT  - Journal Article
DEP - 20090326
PL  - Korea (South)
TA  - Clin Exp Otorhinolaryngol
JT  - Clinical and experimental otorhinolaryngology
JID - 101474010
PMC - PMC2671827
OTO - NOTNLM
OT  - Galectin-8
OT  - Immunohistochemistry
OT  - Larynx
OT  - Squamous cell carcinoma
EDAT- 2009/05/13 09:00
MHDA- 2009/05/13 09:01
PMCR- 2009/03/01
CRDT- 2009/05/13 09:00
PHST- 2008/10/07 00:00 [received]
PHST- 2008/12/09 00:00 [accepted]
PHST- 2009/05/13 09:00 [entrez]
PHST- 2009/05/13 09:00 [pubmed]
PHST- 2009/05/13 09:01 [medline]
PHST- 2009/03/01 00:00 [pmc-release]
AID - 10.3342/ceo.2009.2.1.13 [doi]
PST - ppublish
SO  - Clin Exp Otorhinolaryngol. 2009 Mar;2(1):13-9. doi: 10.3342/ceo.2009.2.1.13. Epub 
      2009 Mar 26.