PMID- 19437410
OWN - NLM
STAT- MEDLINE
DCOM- 20091214
LR  - 20191210
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 19
IP  - 10
DP  - 2009 Oct
TI  - Exercise enhances hippocampal-dependent learning in the rat: evidence for a 
      BDNF-related mechanism.
PG  - 973-80
LID - 10.1002/hipo.20631 [doi]
AB  - Short periods of forced exercise have been reported to selectively induce 
      enhancements in hippocampal-dependent cognitive function, possibly via 
      brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we 
      report that 1 week of treadmill running significantly enhanced both object 
      displacement (spatial) and object substitution (nonspatial) learning. These 
      behavioral changes were accompanied by increased expression of BDNF protein in 
      the dentate gyrus, hippocampus, and perirhinal cortex. The effects of exercise on 
      object substitution were mimicked by intracerebroventricular injection of BDNF 
      protein. These data are consistent with the hypothesis that exercise has the 
      potential to enhance cognitive function in young healthy rats, possibly via a 
      mechanism involving increased BDNF expression in specific brain regions.
CI  - Copyright 2008 Wiley-Liss, Inc.
FAU - Griffin, Eadaoin W
AU  - Griffin EW
AD  - Department of Physiology, School of Medicine, and Trinity College Institute of 
      Neuroscience, University of Dublin, Trinity College, Dublin, Ireland.
FAU - Bechara, Ranya G
AU  - Bechara RG
FAU - Birch, Amy M
AU  - Birch AM
FAU - Kelly, Aine M
AU  - Kelly AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dentate Gyrus/physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*physiology
MH  - Learning/*physiology
MH  - Male
MH  - Neuropsychological Tests
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Recognition, Psychology/physiology
MH  - Running/*physiology
MH  - Space Perception/*physiology
MH  - Temporal Lobe/physiology
MH  - Time Factors
EDAT- 2009/05/14 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/05/14 09:00
PHST- 2009/05/14 09:00 [entrez]
PHST- 2009/05/14 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.1002/hipo.20631 [doi]
PST - ppublish
SO  - Hippocampus. 2009 Oct;19(10):973-80. doi: 10.1002/hipo.20631.