PMID- 19438577
OWN - NLM
STAT- MEDLINE
DCOM- 20090727
LR  - 20181201
IS  - 1365-2230 (Electronic)
IS  - 0307-6938 (Linking)
VI  - 34
IP  - 5
DP  - 2009 Jul
TI  - Pemphigus-like lesions induced by imiquimod.
PG  - e60-2
LID - 10.1111/j.1365-2230.2008.03181.x [doi]
AB  - Imiquimod is an immunomodifier recently approved for the treatment of superficial 
      basal cell carcinomas (sBCC). Although local adverse events (AEs) are the most 
      commonly reported, systemic AEs have also been described. We present the case of 
      a 60-year-old woman who, after the application of two sachets of imiquimod cream 
      per day for 5 days/week to two large sBCCs, developed pemphigus-like lesions both 
      at and distant from the application site. Histological examination of a skin 
      biopsy found intraepidermal acantholytic blistering but results of direct 
      immunofluorescence examination were negative. The lesions resolved after 
      cessation of imiquimod. Two previous cases of imiquimod-induced pemphigus have 
      been reported, but this is the first case with lesions distant from the site of 
      application. We suggest that systemic absorption of the drug or greatly increased 
      synthesis of cytokines could explain this reaction and recommend the use of low 
      doses of imiquimod in the treatment of large or multiple sBCCs.
FAU - Bauza, A
AU  - Bauza A
AD  - Department of Dermatology, Son Dureta University Hospital, Palma de Mallorca, 
      Mallorca, Spain. abauza@aedv.es
FAU - Del Pozo, L J
AU  - Del Pozo LJ
FAU - Saus, C
AU  - Saus C
FAU - Martin, A
AU  - Martin A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090505
PL  - England
TA  - Clin Exp Dermatol
JT  - Clinical and experimental dermatology
JID - 7606847
RN  - 0 (Aminoquinolines)
RN  - 0 (Antineoplastic Agents)
RN  - P1QW714R7M (Imiquimod)
SB  - IM
MH  - Aminoquinolines/*adverse effects
MH  - Antineoplastic Agents/*adverse effects
MH  - Carcinoma, Basal Cell/drug therapy
MH  - Drug Eruptions/*etiology/pathology
MH  - Female
MH  - Humans
MH  - Imiquimod
MH  - Middle Aged
MH  - Pemphigus/*etiology/pathology
MH  - Skin Neoplasms/drug therapy
EDAT- 2009/05/15 09:00
MHDA- 2009/07/28 09:00
CRDT- 2009/05/15 09:00
PHST- 2009/05/15 09:00 [entrez]
PHST- 2009/05/15 09:00 [pubmed]
PHST- 2009/07/28 09:00 [medline]
AID - CED3181 [pii]
AID - 10.1111/j.1365-2230.2008.03181.x [doi]
PST - ppublish
SO  - Clin Exp Dermatol. 2009 Jul;34(5):e60-2. doi: 10.1111/j.1365-2230.2008.03181.x. 
      Epub 2009 May 5.