PMID- 19439962
OWN - NLM
STAT- MEDLINE
DCOM- 20090629
LR  - 20090514
IS  - 1421-9875 (Electronic)
IS  - 0257-2753 (Linking)
VI  - 27
IP  - 1
DP  - 2009
TI  - Weakly acidic reflux.
PG  - 58-61
LID - 10.1159/000210105 [doi]
AB  - The advent of pH impedance monitoring has allowed assessment of the role of 
      weakly acidic reflux, in addition to the traditionally considered acid reflux, in 
      the pathophysiology of gastroesophageal reflux disease. Typical reflux symptoms 
      studied off proton pump inhibitor (PPI) therapy are mainly associated with acid 
      reflux events, while weakly acidic reflux is only significantly associated with 
      symptom occurrence when assessed on PPI therapy. A major role in weakly acidic 
      reflux in the absence of acid suppressive therapy has only been established for 
      reflux-related cough. Further studies are needed to address the impact of weakly 
      acidic reflux on the management and therapeutic choices in gastroesophageal 
      reflux disease patients with symptoms that persist on PPI therapy. There is a 
      lack of outcomes studies addressing the issue of reflux inhibitors and surgery 
      for weakly acidic reflux that persists in patients on PPIs.
FAU - Tack, Jan
AU  - Tack J
AD  - Department of Pathophysiology, University of Leuven, Leuven, Belgium. 
      jan.tack@med.kuleuven.ac.be
FAU - Blondeau, Kathleen
AU  - Blondeau K
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090508
PL  - Switzerland
TA  - Dig Dis
JT  - Digestive diseases (Basel, Switzerland)
JID - 8701186
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Drug Resistance
MH  - Esophageal pH Monitoring
MH  - Gastric Acid/*metabolism
MH  - Gastroesophageal Reflux/*drug therapy/*physiopathology/surgery
MH  - Humans
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Treatment Failure
RF  - 42
EDAT- 2009/05/15 09:00
MHDA- 2009/06/30 09:00
CRDT- 2009/05/15 09:00
PHST- 2009/05/15 09:00 [entrez]
PHST- 2009/05/15 09:00 [pubmed]
PHST- 2009/06/30 09:00 [medline]
AID - 000210105 [pii]
AID - 10.1159/000210105 [doi]
PST - ppublish
SO  - Dig Dis. 2009;27(1):58-61. doi: 10.1159/000210105. Epub 2009 May 8.