PMID- 19439981
OWN - NLM
STAT- MEDLINE
DCOM- 20091012
LR  - 20131121
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 150
IP  - 2
DP  - 2009
TI  - The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene 
      diisocyanate-induced occupational asthma.
PG  - 156-63
LID - 10.1159/000218118 [doi]
AB  - BACKGROUND: Although the pathogenesis of toluene diisocyanate (TDI)-induced 
      occupational asthma (TDI-OA) is incompletely understood, several studies have 
      suggested immunologic mechanisms, including specific IgE responses. A few studies 
      have suggested human leukocyte antigen (HLA) associations with TDI-induced asthma 
      in Western countries, but this is the first investigation of associations between 
      HLA class I and II alleles and TDI-induced asthma patients in Asia, using 
      high-resolution analysis. METHODS: Patients with TDI-OA (n = 84), asymptomatic 
      exposed controls (AECs, n = 47) and unexposed normal controls (NCs, n = 127) were 
      enrolled. HLA class I and II genotyping was performed by the direct DNA 
      sequencing analysis. Specific serum IgE antibodies to the vapor type TDI-albumin 
      conjugate were measured by ELISA. RESULTS: There was no significant association 
      between the allele frequencies and the phenotype of TDI-OA. However, the 
      frequency of the HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype was significantly 
      higher in TDI-OA patients (19%) than in AEC (2.1%, p = 0.007, OR 4.429, CI 
      1.497-13.103) or NC (3.1%, p < 0.001, OR 7.235, CI 2.236-22.510) subjects, with 
      statistical significance persisting after correction for multiple comparisons. 
      DQB1*0402 was significantly associated with the presence of specific IgE to 
      TDI-albumin conjugates in serum (p = 0.006, OR 4.552, CI 1.540-13.449). This p 
      value remained significant after correction for multiple comparison. CONCLUSION: 
      The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype may be a genetic marker for the 
      development of TDI-induced asthma in Koreans. Several HLA alleles that enhance 
      specific IgE sensitization in exposed subjects are indicated.
CI  - (c) 2009 S. Karger AG, Basel.
FAU - Choi, Jeong-Hee
AU  - Choi JH
AD  - Department of Internal Medicine, Hallym University, Anyang, Korea.
FAU - Lee, Kyung-Wha
AU  - Lee KW
FAU - Kim, Cheol-Woo
AU  - Kim CW
FAU - Park, Choon-Sik
AU  - Park CS
FAU - Lee, Hyun-Young
AU  - Lee HY
FAU - Hur, Gyu-Young
AU  - Hur GY
FAU - Kim, Seung-Hyun
AU  - Kim SH
FAU - Hong, Chein-Soo
AU  - Hong CS
FAU - Jang, An-Soo
AU  - Jang AS
FAU - Park, Hae-Sim
AU  - Park HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090512
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1*05:01 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:01 antigen)
RN  - 0 (Membrane Glycoproteins)
RN  - 17X7AFZ1GH (Toluene 2,4-Diisocyanate)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Asthma/*chemically induced/*genetics/physiopathology
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Gene Frequency/genetics
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Korea
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Middle Aged
MH  - Occupational Diseases/chemically induced/*genetics/immunology
MH  - Risk Factors
MH  - Toluene 2,4-Diisocyanate/*adverse effects/immunology
EDAT- 2009/05/15 09:00
MHDA- 2009/10/13 06:00
CRDT- 2009/05/15 09:00
PHST- 2008/08/27 00:00 [received]
PHST- 2008/12/23 00:00 [accepted]
PHST- 2009/05/15 09:00 [entrez]
PHST- 2009/05/15 09:00 [pubmed]
PHST- 2009/10/13 06:00 [medline]
AID - 000218118 [pii]
AID - 10.1159/000218118 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2009;150(2):156-63. doi: 10.1159/000218118. Epub 2009 
      May 12.