PMID- 19440500
OWN - NLM
STAT- MEDLINE
DCOM- 20090702
LR  - 20211020
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 117
IP  - 4
DP  - 2009 Apr
TI  - Persistent organic pollutant residues in human fetal liver and placenta from 
      Greater Montreal, Quebec: a longitudinal study from 1998 through 2006.
PG  - 605-10
LID - 10.1289/ehp.0800205 [doi]
AB  - BACKGROUND: There is general concern that persistent organic pollutants (POPs) 
      found in the environment, wildlife, food, water, house dust, human tissues, and 
      fluids may alter normal human physiologic activities (e.g., fetal development, 
      immune and endocrine systems). Although the levels of some POPs [polychlorinated 
      biphenyls (PCBs) and organochlorine pesticides (OCs)] in these matrices have 
      decreased after their ban, others [polybrominated diphenyl ethers (PBDEs)] have 
      increased in recent years. OBJECTIVE: To determine the longitudinal trend of 
      specific POPs in human fetal tissues for risk assessment purposes. METHODS: We 
      analyzed early to mid-gestation fetal liver (n = 52) and placental (n = 60) 
      tissues, obtained after elective abortions during 1998-2006, for selected PBDEs, 
      PCBs, and OCs using gas chromatography-mass spectroscopy. RESULTS: Total PBDEs in 
      fetal liver increased over time (mean +/- SE: 1998, 284.4 +/- 229.8 ng/g lipid; 
      2006, 1,607.7 +/- 605.9; p < 0.03), whereas placental levels were generally 
      lower, with no clear trend. Low levels of PCBs and OCs varied yearly, with no 
      evident trend. The major analytes in 1998 were OCs (liver, 49%; placenta, 71%), 
      whereas the major analytes in 2006 were PBDEs (liver, 89%; placenta, 98%). The 
      1998-2006 tissue PBDE congener profile is similar to that of DE-71, a commercial 
      primarily pentabrominated diphenyl ether mixture manufactured in North America. 
      CONCLUSIONS: Although commercial production of penta- and octa-brominated 
      diphenyl ethers in North America was halted in 2004, their concentrations in 
      fetal liver and placenta are now greater than the tissue burdens for the analyzed 
      OCs and PCBs. Our findings also demonstrate that PBDEs accumulate within the 
      fetal compartment at a very early stage in gestation.
FAU - Doucet, Josee
AU  - Doucet J
AD  - Health Canada, Health Products and Food Branch, Ottawa, Ontario, Canada.
FAU - Tague, Brett
AU  - Tague B
FAU - Arnold, Douglas L
AU  - Arnold DL
FAU - Cooke, Gerard M
AU  - Cooke GM
FAU - Hayward, Stephen
AU  - Hayward S
FAU - Goodyer, Cynthia G
AU  - Goodyer CG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081210
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aborted Fetus/chemistry
MH  - Environmental Pollutants/*analysis
MH  - Female
MH  - Halogenated Diphenyl Ethers/*analysis
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*analysis
MH  - Liver/*chemistry/embryology
MH  - Longitudinal Studies
MH  - Placenta/*chemistry
MH  - Polychlorinated Biphenyls/*analysis
MH  - Quebec
PMC - PMC2679605
OTO - NOTNLM
OT  - OCs
OT  - PBDEs
OT  - PCBs
OT  - POPs
OT  - fetus
OT  - human
OT  - liver
OT  - placenta
EDAT- 2009/05/15 09:00
MHDA- 2009/07/03 09:00
PMCR- 2009/04/01
CRDT- 2009/05/15 09:00
PHST- 2008/09/18 00:00 [received]
PHST- 2008/12/10 00:00 [accepted]
PHST- 2009/05/15 09:00 [entrez]
PHST- 2009/05/15 09:00 [pubmed]
PHST- 2009/07/03 09:00 [medline]
PHST- 2009/04/01 00:00 [pmc-release]
AID - ehp-117-605 [pii]
AID - 10.1289/ehp.0800205 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2009 Apr;117(4):605-10. doi: 10.1289/ehp.0800205. Epub 
      2008 Dec 10.