PMID- 19440557
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20161125
IS  - 0214-0934 (Print)
IS  - 0214-0934 (Linking)
VI  - 22
IP  - 3
DP  - 2009 Apr
TI  - Syk kinase inhibitors in allergic diseases.
PG  - 146-50
LID - 10.1358/dnp.2009.22.3.1354124 [doi]
AB  - Recent advances in the understanding of allergic mechanisms have highlighted the 
      role of immunoglobulin E (IgE) signaling in the mast cell. One of the most 
      important kinases in the IgE signaling pathway is spleen tyrosine kinase (Syk) 
      which has a critical function early in the signaling cascade following binding of 
      allergen to receptor bound IgE on the mast cell. A number of Syk inhibitors have 
      now been developed which have been shown to effectively inhibit IgE-driven mast 
      cell degranulation and release of inflammatory cytokines in vitro and inhibit 
      allergic responses in a variety of in vivo models. In humans, allergen-driven 
      symptoms were reduced in allergic rhinitic patients exposed to tree pollen in an 
      outdoor environment following intranasal dosing of the Syk inhibitor R-112. Syk 
      therefore represents a promising target for therapeutic intervention in allergic 
      diseases.
CI  - Copyright 2009 Prous Science, S.A.U. or its licensors. All rights reserved.
FAU - Denyer, Jane
AU  - Denyer J
AD  - Respiratory CEDD, GlaxoSmithKline Medicines Research Centre, Stevenage, Herts SG1 
      2NY, UK. jane.c.denyer@gsk.com
FAU - Patel, Vipul
AU  - Patel V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Drug News Perspect
JT  - Drug news & perspectives
JID - 8809164
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (SYK protein, human)
RN  - EC 2.7.10.2 (Syk Kinase)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Drug Delivery Systems
MH  - Drug Discovery
MH  - Enzyme Inhibitors/chemistry/pharmacology/therapeutic use
MH  - Humans
MH  - Hypersensitivity/*drug therapy
MH  - Intracellular Signaling Peptides and Proteins/*antagonists & 
      inhibitors/*physiology
MH  - Mast Cells/physiology
MH  - Models, Biological
MH  - Molecular Structure
MH  - Protein-Tyrosine Kinases/*antagonists & inhibitors/*physiology
MH  - Syk Kinase
RF  - 37
EDAT- 2009/05/15 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/05/15 09:00
PHST- 2009/05/15 09:00 [entrez]
PHST- 2009/05/15 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - 1354124 [pii]
AID - 10.1358/dnp.2009.22.3.1354124 [doi]
PST - ppublish
SO  - Drug News Perspect. 2009 Apr;22(3):146-50. doi: 10.1358/dnp.2009.22.3.1354124.