PMID- 19441883
OWN - NLM
STAT- MEDLINE
DCOM- 20091113
LR  - 20220410
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 29
IP  - 6
DP  - 2009 Jun
TI  - Monocyte chemoattractant protein-1 (MCP-1): an overview.
PG  - 313-26
LID - 10.1089/jir.2008.0027 [doi]
AB  - Chemokines constitute a family of chemoattractant cytokines and are subdivided 
      into four families on the basis of the number and spacing of the conserved 
      cysteine residues in the N-terminus of the protein. Chemokines play a major role 
      in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in 
      inducing chemotaxis through the activation of G-protein-coupled receptors. 
      Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that 
      regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its 
      receptor CCR2 have been demonstrated to be induced and involved in various 
      diseases. Migration of monocytes from the blood stream across the vascular 
      endothelium is required for routine immunological surveillance of tissues, as 
      well as in response to inflammation. This review will discuss these biological 
      processes and the structure and function of CCL2.
FAU - Deshmane, Satish L
AU  - Deshmane SL
AD  - Department of Neuroscience, Temple University School of Medicine, Philadelphia, 
      PA 19140, USA.
FAU - Kremlev, Sergey
AU  - Kremlev S
FAU - Amini, Shohreh
AU  - Amini S
FAU - Sawaya, Bassel E
AU  - Sawaya BE
LA  - eng
GR  - R01 MH070294/MH/NIMH NIH HHS/United States
GR  - R01 MH070294-05/MH/NIMH NIH HHS/United States
GR  - R01 NS059327/NS/NINDS NIH HHS/United States
GR  - R01 NS059327-03/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/immunology/metabolism
MH  - Chemokine CCL2/chemistry/genetics/immunology/*metabolism
MH  - Chemotaxis/immunology
MH  - Gene Expression Regulation
MH  - Genetic Predisposition to Disease
MH  - HIV Infections/*immunology/metabolism
MH  - HIV-1/*immunology/pathogenicity
MH  - Humans
MH  - *Immunotherapy
MH  - Monocytes/immunology/*metabolism/pathology
MH  - Polymorphism, Genetic
MH  - Receptors, CCR2/genetics/immunology/metabolism
MH  - Vascular Diseases/immunology/metabolism
MH  - Virulence
PMC - PMC2755091
MID - NIHMS134056
EDAT- 2009/05/16 09:00
MHDA- 2009/11/17 06:00
PMCR- 2010/06/01
CRDT- 2009/05/16 09:00
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2009/11/17 06:00 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - 10.1089/jir.2008.0027 [pii]
AID - 10.1089/jir.2008.0027 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2009 Jun;29(6):313-26. doi: 10.1089/jir.2008.0027.