PMID- 19441905
OWN - NLM
STAT- MEDLINE
DCOM- 20090727
LR  - 20090515
IS  - 1744-7674 (Electronic)
IS  - 1354-3776 (Linking)
VI  - 19
IP  - 3
DP  - 2009 Mar
TI  - Recent developments in CCR2 antagonists.
PG  - 295-303
LID - 10.1517/13543770902755129 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a major chemoattractant for 
      monocytes and memory T cells by means of their binding to its specific 
      cell-surface receptor, CC-chemokine receptor-2 (CCR2). CCR2 belongs to the 
      G-protein-coupled seven-transmembrane receptor superfamily. The evidence in favor 
      of CCR2 and MCP-1 having dominant roles in monocyte chemotaxis and chronic 
      inflammation was provided by CCR2 and MCP-1 knockout mice. It has been recognized 
      that CCR2 antagonists are potential therapeutic agents in preventing, treating, 
      or ameliorating a CCR2-mediated inflammatory syndrome or disease such as 
      psoriasis, uveitis, rheumatoid arthritis, multiple sclerosis, asthma, obesity, 
      and chronic obstructive pulmonary disease. This review summarizes recent 
      developments in small-molecule CCR2 antagonists disclosed by patent applications 
      published between 2005 and 2008 and related publications.
FAU - Xia, Mingde
AU  - Xia M
AD  - Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development LLC, 
      Cranbury, NJ 08512, USA. mxia@its.jnj.com
FAU - Sui, Zhihua
AU  - Sui Z
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Ther Pat
JT  - Expert opinion on therapeutic patents
JID - 9516419
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Chemokine CCL2/*metabolism
MH  - Chemotaxis/physiology
MH  - Disease Models, Animal
MH  - Drug Design
MH  - Humans
MH  - Inflammation/*drug therapy/physiopathology
MH  - Monocytes/metabolism
MH  - Patents as Topic
MH  - Receptors, CCR2/*antagonists & inhibitors
RF  - 42
EDAT- 2009/05/16 09:00
MHDA- 2009/07/28 09:00
CRDT- 2009/05/16 09:00
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2009/07/28 09:00 [medline]
AID - 10.1517/13543770902755129 [doi]
PST - ppublish
SO  - Expert Opin Ther Pat. 2009 Mar;19(3):295-303. doi: 10.1517/13543770902755129.