PMID- 19442161
OWN - NLM
STAT- MEDLINE
DCOM- 20090727
LR  - 20191111
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 6
IP  - 2
DP  - 2009 May
TI  - Angelica injection improves functional recovery and motoneuron maintenance with 
      increased expression of brain derived neurotrophic factor and nerve growth 
      factor.
PG  - 117-23
AB  - This study assessed the neuroprotective effects of angelica injection in the rat 
      sciatic nerve crush injury (SCI). Forty eight male Sprague Dawley rats were 
      randomly divided into 4 groups: one was the sham group (S), which received sham 
      surgery and given saline injection and the others were received SCI surgery and 
      given saline injection, high and low dose angelica injection for 4 weeks, 
      respectively. The sciatic functional index (SFI) in walking-track analysis, 
      conductive velocity (CV), the number of fluorogold labeled motoneurons, and the 
      expression patterns of brain derived neurotrophic factor (BDNF) and nerve growth 
      factor (NGF) in the sciatic nerve and spine were examined. The results showed 
      that SFI descended gradually on day 7, and dropped more quickly on day 28 in 
      treatment groups (Low and High dose group). The CV in treatment groups was higher 
      than control group (C). The numbers of motoneurons in treatment groups were 
      larger than C group (P<0.05), but less than that in S group (P<0.01). The 
      expressions of BDNF and NGF protein in the groups received SCI surgery were 
      significantly lower than in S group, but the protein expressions in the groups 
      received angelica injections were significantly higher than that in C group 
      (P<0.01). These findings suggested that angelica injection can improve the 
      sciatic nerve crush injury, and the mechanism might be through the increase of 
      BDNF and NGF protein expression.
FAU - Cui, Qin
AU  - Cui Q
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, No 169 Donghu Road, 
      Wuchang District, Wuhan, 430071, China.
FAU - Zhang, Junjian
AU  - Zhang J
FAU - Zhang, Lei
AU  - Zhang L
FAU - Li, Ruiling
AU  - Li R
FAU - Liu, Hui
AU  - Liu H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Plant Preparations)
RN  - 0 (Stilbamidines)
SB  - IM
MH  - Analysis of Variance
MH  - Angelica/*chemistry
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - Motor Neurons/*drug effects/physiology
MH  - Nerve Growth Factors/*metabolism
MH  - Neural Conduction/drug effects/physiology
MH  - Phytotherapy/*methods
MH  - Plant Preparations/*administration & dosage
MH  - Psychomotor Performance/drug effects
MH  - Radioimmunoprecipitation Assay/methods
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function/*drug effects
MH  - Sciatic Neuropathy/drug therapy/pathology/physiopathology
MH  - Stilbamidines/metabolism
MH  - Time Factors
EDAT- 2009/05/16 09:00
MHDA- 2009/07/28 09:00
CRDT- 2009/05/16 09:00
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2009/07/28 09:00 [medline]
AID - 10.2174/156720209788185641 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2009 May;6(2):117-23. doi: 10.2174/156720209788185641.