PMID- 19442309
OWN - NLM
STAT- MEDLINE
DCOM- 20091028
LR  - 20211020
IS  - 1466-609X (Electronic)
IS  - 1364-8535 (Print)
IS  - 1364-8535 (Linking)
VI  - 13
IP  - 3
DP  - 2009
TI  - Triggering receptor expressed on myeloid cells-1 expression on monocytes is 
      associated with inflammation but not with infection in acute pancreatitis.
PG  - R69
LID - 10.1186/cc7876 [doi]
AB  - INTRODUCTION: Acute pancreatitis (AP) is usually a mild and self-limiting 
      disease, but some patients develop a severe form that is associated with high 
      mortality. In AP, local inflammation is followed first by the systemic 
      inflammatory response syndrome and then by the compensatory anti-inflammatory 
      response syndrome, which is defined by low human leukocyte antigen (HLA)-DR 
      expression on monocytes, increased concentration of the anti-inflammatory 
      cytokine IL-10, and decreased monocyte function. Our aim was to measure the 
      expression of triggering receptor expressed on myeloid cells (TREM)-1 (a proposed 
      marker of infection or inflammation) and HLA-DR on monocytes, and the serum 
      concentrations of IL-6 (a proinflammatory cytokine) and IL-10 in patients with AP 
      to determine whether these markers can identify patients at high risk of 
      developing severe AP or infection. METHODS: Fifty healthy volunteers, 18 patients 
      with mild AP, and 11 patients with severe AP were included in this study. Samples 
      were taken at admission and one and three days later. TREM-1 and HLA-DR 
      expression was evaluated by flow cytometry, and soluble TREM-1, IL-6 and IL-10 
      concentrations were measured by ELISA. RESULTS: TREM-1 expression was higher in 
      patients with AP than in healthy volunteers, but there was no difference between 
      patients with mild and severe AP. TREM-1 expression was not associated with 
      mortality or with the presence of infection. Soluble TREM-1 concentration in 
      serum was higher in non-survivors than in survivors. HLA-DR expression was lower 
      and IL-6 concentration higher in patients with severe AP and in infected 
      patients. CONCLUSIONS: Increased TREM-1 expression was associated with the 
      presence of inflammation but not infection in AP. In patients with AP, low HLA-DR 
      expression and high IL-6 concentration could predict severity and infection in 
      samples taken shortly after admission.
FAU - Ferat-Osorio, Eduardo
AU  - Ferat-Osorio E
AD  - Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical 
      Centre Siglo XXI, Mexican Institute for Social Security, Mexico City, Mexico. 
      eduardoferat@prodigy.net.mx
FAU - Wong-Baeza, Isabel
AU  - Wong-Baeza I
FAU - Esquivel-Callejas, Noemi
AU  - Esquivel-Callejas N
FAU - Figueroa-Figueroa, Silvia
AU  - Figueroa-Figueroa S
FAU - Duarte-Rojo, Andres
AU  - Duarte-Rojo A
FAU - Guzman-Valdivia-Gomez, Gilberto
AU  - Guzman-Valdivia-Gomez G
FAU - Rodea-Rosas, Heriberto
AU  - Rodea-Rosas H
FAU - Torres-Gonzalez, Ruben
AU  - Torres-Gonzalez R
FAU - Sanchez-Fernandez, Patricio
AU  - Sanchez-Fernandez P
FAU - Arriaga-Pizano, Lourdes
AU  - Arriaga-Pizano L
FAU - Lopez-Macias, Constantino
AU  - Lopez-Macias C
FAU - Robles-Diaz, Guillermo
AU  - Robles-Diaz G
FAU - Isibasi, Armando
AU  - Isibasi A
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20090514
PL  - England
TA  - Crit Care
JT  - Critical care (London, England)
JID - 9801902
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-6)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (TREM1 protein, human)
RN  - 0 (Triggering Receptor Expressed on Myeloid Cells-1)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
CIN - Crit Care. 2009;13(3):152. PMID: 19519945
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - HLA-DR Antigens/*metabolism
MH  - Humans
MH  - Infections/metabolism
MH  - Interleukin-10/*blood
MH  - Interleukin-6/*blood
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Pancreatitis/*diagnosis/metabolism
MH  - Receptors, Immunologic/*metabolism
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - Triggering Receptor Expressed on Myeloid Cells-1
PMC - PMC2717428
EDAT- 2009/05/16 09:00
MHDA- 2009/10/29 06:00
PMCR- 2009/05/14
CRDT- 2009/05/16 09:00
PHST- 2009/03/18 00:00 [received]
PHST- 2009/05/05 00:00 [revised]
PHST- 2009/05/14 00:00 [accepted]
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2009/10/29 06:00 [medline]
PHST- 2009/05/14 00:00 [pmc-release]
AID - cc7876 [pii]
AID - 10.1186/cc7876 [doi]
PST - ppublish
SO  - Crit Care. 2009;13(3):R69. doi: 10.1186/cc7876. Epub 2009 May 14.