PMID- 19442695
OWN - NLM
STAT- MEDLINE
DCOM- 20100114
LR  - 20091019
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 30
IP  - 11
DP  - 2009 Nov
TI  - Melanin-concentrating hormone and melanin-concentrating hormone receptors in 
      mammalian skin physiopathology.
PG  - 2071-5
LID - 10.1016/j.peptides.2009.04.025 [doi]
AB  - To date, there is a dearth of evidence to support functions for 
      melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptors 
      (MCH-R) in mammalian skin physiology including pigmentation, inflammation and 
      immune responses and skin cell proliferation. Much research is therefore still 
      needed to define the roles of the hormone and its receptors in mammalian skin. 
      This will be a crucial step to identifying pathogenic mechanisms that may involve 
      the MCH/MCH-R system in the context of inflammatory and autoimmune skin diseases 
      as well as skin cancers. The following review summarizes the studies which have 
      been carried out to examine the expression and function of MCH and MCH-R in 
      mammalian skin. Recent findings with regard to humoral immune responses to the 
      MCH-R1 in patients with the skin depigmenting disease vitiligo are also 
      discussed.
FAU - Kemp, E Helen
AU  - Kemp EH
AD  - Department of Human Metabolism, University of Sheffield, United Kingdom. 
      e.h.kemp@sheffield.ac.uk
FAU - Weetman, Anthony P
AU  - Weetman AP
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090513
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Hypothalamic Hormones)
RN  - 0 (Melanins)
RN  - 0 (Pituitary Hormones)
RN  - 0 (Receptors, Pituitary Hormone)
RN  - 0 (melanin-concentrating hormone receptor)
RN  - 67382-96-1 (melanin-concentrating hormone)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Hypothalamic Hormones/genetics/metabolism/*physiology
MH  - Mammals/*metabolism
MH  - Melanins/genetics/metabolism/*physiology
MH  - Pituitary Hormones/genetics/metabolism/*physiology
MH  - Receptors, Pituitary Hormone/genetics/*immunology/*metabolism
MH  - Skin/*metabolism/*pathology
MH  - Skin Pigmentation/genetics/physiology
RF  - 39
EDAT- 2009/05/16 09:00
MHDA- 2010/01/15 06:00
CRDT- 2009/05/16 09:00
PHST- 2008/12/08 00:00 [received]
PHST- 2009/04/29 00:00 [revised]
PHST- 2009/04/30 00:00 [accepted]
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2010/01/15 06:00 [medline]
AID - S0196-9781(09)00171-5 [pii]
AID - 10.1016/j.peptides.2009.04.025 [doi]
PST - ppublish
SO  - Peptides. 2009 Nov;30(11):2071-5. doi: 10.1016/j.peptides.2009.04.025. Epub 2009 
      May 13.