PMID- 19443297
OWN - NLM
STAT- MEDLINE
DCOM- 20091006
LR  - 20161013
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 108
IP  - 5
DP  - 2009 May
TI  - HLA-DR-matched parental donors for allogeneic hematopoietic stem cell 
      transplantation in patients with high-risk acute leukemia.
PG  - 423-7
LID - 10.1016/S0929-6646(09)60087-5 [doi]
AB  - The immunomodulating effect of human leukocyte antigen (HLA)-DR and the central 
      role of CD4 T cells in alloimmunity provide clues suggesting that HLA-DR-matched, 
      partially mismatched related donors could be feasible alternative donors of 
      allogeneic hematopoietic stem cells for transplantations (allo-HSCT). We describe 
      our experience with allo-HSCT in eight patients with high-risk acute leukemia; 
      donors included one of each of the parents. Among the eight patients, seven were 
      identical HLA-DR matches with the donors. The stem cells were not manipulated in 
      vitro. Graft-versus-host disease (GVHD) prophylaxis consisted of antithymocyte 
      globulin, cyclosporine, and methotrexate. All patients had successful trilineage 
      engraftment. Only one patient had grade 2-4 acute GVHD. Two patients died before 
      day +100 due to complications. At the end of follow-up, four patients had 
      survived for 18-48 months and three are alive and without relapse. Our results 
      suggest that HLA-DR fully-matched parents are feasible alternative donors for 
      allo-HSCT in patients with high-risk acute leukemia under an intensive 
      conditioning regimen.
FAU - Wu, Shang-Ju
AU  - Wu SJ
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Yao, Ming
AU  - Yao M
FAU - Tang, Jih-Luh
AU  - Tang JL
FAU - Ko, Bo-Sheng
AU  - Ko BS
FAU - Tien, Hwei-Fang
AU  - Tien HF
FAU - Chen, Yao-Chang
AU  - Chen YC
LA  - eng
PT  - Journal Article
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Graft vs Host Disease/etiology
MH  - HLA-DR Antigens/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Leukemia/mortality/*therapy
MH  - *Living Donors
MH  - Male
MH  - *Parents
MH  - Transplantation, Homologous
EDAT- 2009/05/16 09:00
MHDA- 2009/10/07 06:00
CRDT- 2009/05/16 09:00
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2009/10/07 06:00 [medline]
AID - S0929-6646(09)60087-5 [pii]
AID - 10.1016/S0929-6646(09)60087-5 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2009 May;108(5):423-7. doi: 10.1016/S0929-6646(09)60087-5.