PMID- 19443534
OWN - NLM
STAT- MEDLINE
DCOM- 20100304
LR  - 20211028
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 34
IP  - 6
DP  - 2009 Dec
TI  - Quadriceps muscle strength in scoliosis.
PG  - 1429-35
LID - 10.1183/09031936.00074008 [doi]
AB  - Quadriceps muscle weakness is an important component of chronic obstructive 
      pulmonary disease (COPD). We hypothesised that quadriceps weakness would also be 
      a feature of restrictive lung disease due to scoliosis. We studied 10 patients 
      with severe scoliosis (median (interquartile range (IQR)) forced expiratory 
      volume in 1 s (FEV(1))() 35.3 (11)% predicted), 10 patients with severe COPD 
      (FEV(1) 26.5 (9.0)% pred) and 10 healthy age-matched adults. We measured 
      quadriceps strength, exercise capacity and analysed quadriceps muscle biopsies 
      for myosin heavy-chain (MyHC) isoform expression and the presence of oxidative 
      stress. Both groups exhibited quadriceps weakness with median (IQR) maximal 
      voluntary contraction force being 46.0 (17.0) kg, 21.5 (21.0) kg and 31.5 (11.0) 
      kg, respectively (p = 0.02 and 0.04, respectively, for each patient group against 
      controls). Oxidative stress was significantly greater in the quadriceps of both 
      restrictive and COPD patients. The scoliosis patients exhibited a decrease in the 
      proportion of MyHC type I compared with controls; median (IQR) 35.3 (18.5)% 
      compared with 47.7 (9.3)%, p = 0.028. The scoliosis patients also showed an 
      increase in MyHC IIx (26.3 (15.5)% compared with 11.3 (13.0)%, p = 0.01. 
      Quadriceps weakness is a feature of severe scoliosis; the similarities between 
      patients with scoliosis and patients with COPD suggest a common aetiology to 
      quadriceps weakness in both conditions.
FAU - Swallow, E B
AU  - Swallow EB
AD  - Muscle Laboratory, Royal Brompton Hospital & NHLI, Imperial College, London, UK.
FAU - Barreiro, E
AU  - Barreiro E
FAU - Gosker, H
AU  - Gosker H
FAU - Sathyapala, S A
AU  - Sathyapala SA
FAU - Sanchez, F
AU  - Sanchez F
FAU - Hopkinson, N S
AU  - Hopkinson NS
FAU - Moxham, J
AU  - Moxham J
FAU - Schols, A
AU  - Schols A
FAU - Gea, J
AU  - Gea J
FAU - Polkey, M I
AU  - Polkey MI
CN  - ENIGMA in COPD project
LA  - eng
GR  - 079686/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090514
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - EC 3.6.4.1 (Myosin Heavy Chains)
SB  - IM
CIN - Eur Respir J. 2009 Dec;34(6):1213-4. PMID: 19948906
CIN - Eur Respir J. 2010 May;35(5):1193-4. PMID: 20436181
MH  - Aged
MH  - Biopsy
MH  - Case-Control Studies
MH  - Exercise
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength
MH  - Muscle Weakness/*physiopathology
MH  - Muscles/pathology
MH  - Myosin Heavy Chains/chemistry
MH  - Pulmonary Disease, Chronic Obstructive/*complications/*physiopathology
MH  - Quadriceps Muscle/*pathology
MH  - Scoliosis/*complications/*physiopathology
PMC - PMC3073323
MID - UKMS34177
OID - NLM: UKMS34177
EDAT- 2009/05/16 09:00
MHDA- 2010/03/05 06:00
PMCR- 2011/04/11
CRDT- 2009/05/16 09:00
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2010/03/05 06:00 [medline]
PHST- 2011/04/11 00:00 [pmc-release]
AID - 09031936.00074008 [pii]
AID - 10.1183/09031936.00074008 [doi]
PST - ppublish
SO  - Eur Respir J. 2009 Dec;34(6):1429-35. doi: 10.1183/09031936.00074008. Epub 2009 
      May 14.