PMID- 19444693
OWN - NLM
STAT- MEDLINE
DCOM- 20101006
LR  - 20211020
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 15
IP  - 3
DP  - 2009 May
TI  - Varicella-zoster virus vasculopathy and central nervous system immune 
      reconstitution inflammatory syndrome with human immunodeficiency virus infection 
      treated with steroids.
PG  - 288-91
LID - 10.1080/13550280902913610 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) is widely recognized and 
      rarely involves the central nervous system (CNS). Patients with acquired 
      immunodeficiency syndrome (AIDS) are at an increased risk for developing CNS-IRIS 
      upon initiation of highly active antiretroviral therapy (HAART). This syndrome 
      can be fatal and requires extreme vigilance in determining if a treatable 
      underlying opportunistic infection exists. We report here a case of 
      varicella-zoster virus (VZV) vasculopathy and CNS-IRIS in a human 
      immunodeficiency virus (HIV)-infected patient who required prolonged steroid 
      treatment for clinical stabilization. There are no established treatment regimens 
      for IRIS and the use of corticosteroids in this syndrome remains controversial. 
      Similar to our patient, severe cases of CNS-IRIS may benefit from high-dose 
      intravenous corticosteroid treatment followed by an oral prednisone taper.
FAU - Newsome, Scott D
AU  - Newsome SD
AD  - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 
      21287, Maryland, USA.
FAU - Nath, Avindra
AU  - Nath A
LA  - eng
GR  - R01 NS056884/NS/NINDS NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (DNA, Viral)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*complications/drug therapy
MH  - Adult
MH  - Anti-HIV Agents/therapeutic use
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Antiretroviral Therapy, Highly Active
MH  - DNA, Viral/cerebrospinal fluid
MH  - Encephalitis, Varicella Zoster/*etiology
MH  - Female
MH  - *HIV-1
MH  - Herpesvirus 3, Human/genetics/*isolation & purification
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*drug therapy
MH  - Methylprednisolone/*therapeutic use
MH  - Vasculitis, Central Nervous System/*etiology
EDAT- 2009/05/16 09:00
MHDA- 2010/10/07 06:00
CRDT- 2009/05/16 09:00
PHST- 2009/05/16 09:00 [entrez]
PHST- 2009/05/16 09:00 [pubmed]
PHST- 2010/10/07 06:00 [medline]
AID - 911196718 [pii]
AID - 10.1080/13550280902913610 [doi]
PST - ppublish
SO  - J Neurovirol. 2009 May;15(3):288-91. doi: 10.1080/13550280902913610.