PMID- 19445991
OWN - NLM
STAT- MEDLINE
DCOM- 20091013
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 7
DP  - 2009 Jul
TI  - Association of human leukocyte antigen class II alleles with severe acute 
      respiratory syndrome in the Vietnamese population.
PG  - 527-31
LID - 10.1016/j.humimm.2009.05.006 [doi]
AB  - Excessive immune response is believed to play a role in the development of severe 
      acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think 
      of an Asian genetic predisposition and contribution of human leukocyte antigen 
      (HLA) to the disease susceptibility. However, past case-control studies showed 
      inconsistent results. In Viet Nam, of 62 patients with SARS, 44 participated in 
      the present study together with 103 individuals who had contact with SARS 
      patients and 50 without contact history. HLA-DRB1*12 was more frequently shown in 
      SARS patients than in controls (corrected p = 0.042). HLA-DRB1*1202, the 
      predominant allele in the Vietnamese population showed the strongest association 
      with SARS in a dominant model (corrected p = 0.0065 and 0.0052, depending on the 
      controls to be compared). Our results and accumulated data on HLA in the Asian 
      populations would help in the understanding of associations with emerging 
      infectious diseases.
FAU - Keicho, Naoto
AU  - Keicho N
AD  - Department of Respiratory Diseases, Research Institute, Tokyo, Japan. 
      nkeicho-tky@umin.ac.jp
FAU - Itoyama, Satoru
AU  - Itoyama S
FAU - Kashiwase, Koichi
AU  - Kashiwase K
FAU - Phi, Nguyen Chi
AU  - Phi NC
FAU - Long, Hoang Thuy
AU  - Long HT
FAU - Ha, Le Dang
AU  - Ha LD
FAU - Ban, Vo Van
AU  - Ban VV
FAU - Hoa, Bach Khanh
AU  - Hoa BK
FAU - Hang, Nguyen Thi Le
AU  - Hang NT
FAU - Hijikata, Minako
AU  - Hijikata M
FAU - Sakurada, Shinsaku
AU  - Sakurada S
FAU - Satake, Masahiro
AU  - Satake M
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
FAU - Sasazuki, Takehiko
AU  - Sasazuki T
FAU - Quy, Tran
AU  - Quy T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090513
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*12:02 antigen)
SB  - IM
MH  - Asian People/genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Severe Acute Respiratory Syndrome/ethnology/*genetics
MH  - Vietnam
PMC - PMC7132661
EDAT- 2009/05/19 09:00
MHDA- 2009/10/14 06:00
PMCR- 2009/05/13
CRDT- 2009/05/19 09:00
PHST- 2009/01/27 00:00 [received]
PHST- 2009/05/07 00:00 [revised]
PHST- 2009/05/08 00:00 [accepted]
PHST- 2009/05/19 09:00 [entrez]
PHST- 2009/05/19 09:00 [pubmed]
PHST- 2009/10/14 06:00 [medline]
PHST- 2009/05/13 00:00 [pmc-release]
AID - S0198-8859(09)00135-9 [pii]
AID - 10.1016/j.humimm.2009.05.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Jul;70(7):527-31. doi: 10.1016/j.humimm.2009.05.006. Epub 2009 
      May 13.