PMID- 19446472
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20091207
IS  - 1096-3618 (Electronic)
IS  - 1044-5323 (Linking)
VI  - 21
IP  - 6
DP  - 2009 Dec
TI  - Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid 
      arthritis and psoriasis.
PG  - 318-27
LID - 10.1016/j.smim.2009.04.002 [doi]
AB  - Talk of numerous genetic risk factors for rheumatoid arthritis (RA) and psoriasis 
      has been percolating for years, but with the exception of the human leukocyte 
      antigen (HLA) region, none have been definitively identified. Recently the 
      results of multiple, well powered, genetic case-control studies have begun to 
      appear providing convincing statistical evidence for at least ten non-HLA related 
      risk genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14, PADI4, 
      PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B, IL13, IL23R, 
      STAT2/IL23A, TNFAIP3, and TNIP1) for psoriasis. These initial, novel findings are 
      beginning to shed light on the molecular pathways pertinent to the individual 
      diseases and highlight the pleiotropic effects of several risk factors as well as 
      the allelic heterogeneity underlying susceptibility to these and other autoimmune 
      diseases.
FAU - Li, Yonghong
AU  - Li Y
AD  - Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA.
FAU - Begovich, Ann B
AU  - Begovich AB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090514
PL  - England
TA  - Semin Immunol
JT  - Seminars in immunology
JID - 9009458
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/ethnology/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Psoriasis/*genetics
RF  - 139
EDAT- 2009/05/19 09:00
MHDA- 2010/02/02 06:00
CRDT- 2009/05/19 09:00
PHST- 2008/12/16 00:00 [received]
PHST- 2009/04/09 00:00 [accepted]
PHST- 2009/05/19 09:00 [entrez]
PHST- 2009/05/19 09:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - S1044-5323(09)00030-X [pii]
AID - 10.1016/j.smim.2009.04.002 [doi]
PST - ppublish
SO  - Semin Immunol. 2009 Dec;21(6):318-27. doi: 10.1016/j.smim.2009.04.002. Epub 2009 
      May 14.