PMID- 19446746
OWN - NLM
STAT- MEDLINE
DCOM- 20090708
LR  - 20090518
IS  - 1873-4456 (Electronic)
IS  - 0165-4608 (Linking)
VI  - 191
IP  - 2
DP  - 2009 Jun
TI  - Three-way complex translocations in infant acute myeloid leukemia with 
      t(7;12)(q36;p13): the incidence and correlation of a HLXB9 overexpression.
PG  - 102-5
LID - 10.1016/j.cancergencyto.2009.02.007 [doi]
AB  - The t(7;12)(q36;p13) is one of the recurrent cytogenetic abnormalities that 
      involves the ETV6 gene. It is found in patients suffering with infantile acute 
      myeloid leukemia (AML). We reviewed the cytogenetic and clinical findings of 215 
      pediatric patients (ages </=17) who were diagnosed with AML to check for 
      abnormalities of 7q and/or 12p. Fluorescence in situ hybridization (FISH) 
      analysis using an ETV6 (12p13) break-apart probe was done to confirm the breakage 
      of the ETV6 gene on 12p. We also performed immunohistochemistry to verify the 
      upregulated expression of the HLXB9 protein, which is coded by the HLXB9 gene at 
      7q36. Three patients (1.4%) with t(7;12) were detected and they made up 15.8% of 
      the patients who were less than 24 months old. New three-way complex 
      translocations were found in two cases - t(5;7;12)(q31;q36;p13) and 
      t(1;7;12)(q25;q36;p13) - and we detected these by performing FISH. All three 
      patients died early during treatment due to multiple organ failure or relapse. 
      HLXB9 overexpression was proven by immunohistochemistry for the first time in 
      this study. In connection with this, we prudently propose that downregulation of 
      the HLXB9 expression may be a new treatment strategy for AML patients with 
      t(7;12).
FAU - Park, Joonhong
AU  - Park J
AD  - Department of Laboratory Medicine, College of Medicine, The Catholic University 
      of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701.
FAU - Kim, Myungshin
AU  - Kim M
FAU - Lim, Jihyang
AU  - Lim J
FAU - Kim, Yonggoo
AU  - Kim Y
FAU - Han, Kyungja
AU  - Han K
FAU - Lee, Jaewook
AU  - Lee J
FAU - Chung, Nak Gyun
AU  - Chung NG
FAU - Cho, Bin
AU  - Cho B
FAU - Kim, Hack Ki
AU  - Kim HK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Homeodomain Proteins)
RN  - 0 (MNX1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Bone Marrow/pathology
MH  - Child
MH  - Child, Preschool
MH  - Chromosome Banding
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 12
MH  - *Chromosomes, Human, Pair 7
MH  - Gene Expression Regulation, Neoplastic
MH  - Homeodomain Proteins/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics/pathology
MH  - Metaphase
MH  - Transcription Factors/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2009/05/19 09:00
MHDA- 2009/07/09 09:00
CRDT- 2009/05/19 09:00
PHST- 2008/12/04 00:00 [received]
PHST- 2009/02/12 00:00 [accepted]
PHST- 2009/05/19 09:00 [entrez]
PHST- 2009/05/19 09:00 [pubmed]
PHST- 2009/07/09 09:00 [medline]
AID - S0165-4608(09)00101-0 [pii]
AID - 10.1016/j.cancergencyto.2009.02.007 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2009 Jun;191(2):102-5. doi: 
      10.1016/j.cancergencyto.2009.02.007.