PMID- 19447929
OWN - NLM
STAT- MEDLINE
DCOM- 20090805
LR  - 20151119
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 36
IP  - 6
DP  - 2009 Jun
TI  - High serum cartilage oligomeric matrix protein determines the subset of patients 
      with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix 
      metalloproteinase-3, and MRI-proven bone erosion.
PG  - 1126-9
LID - 10.3899/jrheum.080926 [doi]
AB  - OBJECTIVE: To identify the significance of serum cartilage oligomeric matrix 
      protein (COMP), a marker of cartilage turnover, in patients with early-stage 
      rheumatoid arthritis (RA) in relation to other serologic variables and magnetic 
      resonance imaging (MRI) features. METHODS: Ninety-eight patients with early-stage 
      RA, whose disease duration from onset was less than 2 years, were enrolled. The 
      objective measures at baseline were Disease Activity Score (DAS28), serum 
      C-reactive protein (CRP), serum matrix metalloproteinase-3 (MMP-3), serum 
      antibodies against cyclic citrullinated peptide (anti-CCP), and MRI features of 
      both wrist and finger joints. The MRI features included the number of sites 
      scored positive for synovitis, bone edema, and bone erosion. RESULTS: Serum COMP 
      concentration was not different among groups identified with low, moderate, and 
      high DAS28-CRP values. However, COMP values were statistically high in subjects 
      positive for bone erosions on MRI compared with the subjects who were negative 
      for bone erosions. A positive correlation of COMP with CRP and with MMP-3 values 
      was also identified. CONCLUSION: Elevation of COMP may reflect joint damage that 
      is dependent on the synovial inflammatory process in early-stage RA.
FAU - Fujikawa, Keita
AU  - Fujikawa K
AD  - Unit of Translational Medicine, Department of Immunology and Rheumatology, 
      Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, 
      Nagasaki 852-8501, Japan.
FAU - Kawakami, Atsushi
AU  - Kawakami A
FAU - Tamai, Mami
AU  - Tamai M
FAU - Uetani, Masataka
AU  - Uetani M
FAU - Takao, Shoichiro
AU  - Takao S
FAU - Arima, Kazuhiko
AU  - Arima K
FAU - Iwamoto, Naoki
AU  - Iwamoto N
FAU - Aramaki, Toshiyuki
AU  - Aramaki T
FAU - Kawashiri, Shinya
AU  - Kawashiri S
FAU - Ichinose, Kunihiro
AU  - Ichinose K
FAU - Kamachi, Makoto
AU  - Kamachi M
FAU - Nakamura, Hideki
AU  - Nakamura H
FAU - Origuchi, Tomoki
AU  - Origuchi T
FAU - Ida, Hiroaki
AU  - Ida H
FAU - Aoyagi, Kiyoshi
AU  - Aoyagi K
FAU - Eguchi, Katsumi
AU  - Eguchi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090515
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Biomarkers)
RN  - 0 (Cartilage Oligomeric Matrix Protein)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Matrilin Proteins)
RN  - 0 (TSP5 protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis, Rheumatoid/*blood/pathology/physiopathology
MH  - Biomarkers/blood
MH  - Bone and Bones/*pathology
MH  - C-Reactive Protein/*analysis
MH  - Cartilage Oligomeric Matrix Protein
MH  - Extracellular Matrix Proteins/*blood
MH  - Female
MH  - Glycoproteins/*blood
MH  - Health Status
MH  - Humans
MH  - Joints/pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Matrilin Proteins
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Synovitis/pathology
MH  - Young Adult
EDAT- 2009/05/19 09:00
MHDA- 2009/08/06 09:00
CRDT- 2009/05/19 09:00
PHST- 2009/05/19 09:00 [entrez]
PHST- 2009/05/19 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
AID - jrheum.080926 [pii]
AID - 10.3899/jrheum.080926 [doi]
PST - ppublish
SO  - J Rheumatol. 2009 Jun;36(6):1126-9. doi: 10.3899/jrheum.080926. Epub 2009 May 15.