PMID- 1944804
OWN - NLM
STAT- MEDLINE
DCOM- 19911203
LR  - 20190918
IS  - 0305-1846 (Print)
IS  - 0305-1846 (Linking)
VI  - 17
IP  - 4
DP  - 1991 Aug
TI  - Cerebral endothelial cell infection by measles virus in subacute sclerosing 
      panencephalitis: ultrastructural and in situ hybridization evidence.
PG  - 289-97
AB  - Infection of vascular endothelium plays a central role in the pathogenesis of 
      acute measles virus infection outside the central nervous system (CNS) but has 
      not been described in the human CNS. An ultrastructural survey was made of blood 
      vessels in five cases of subacute sclerosing panencephalitis (SSPE) to determine 
      whether or not infection of cerebral vascular endothelium occurred in this 
      persistent fatal CNS disease caused by measles virus. Morbillivirus nucleocapsids 
      were found in a few endothelial cells in three necropsy cases but not in the 
      limited tissue available from two biopsies. In a severe parenchymal lesion in one 
      necropsied case, endothelial cells hybridized in situ with a biotinylated probe 
      specific for the N genomic RNA of measles virus. It is concluded that human 
      cerebral endothelium is susceptible to measles virus infection.
FAU - Kirk, J
AU  - Kirk J
AD  - Multiple Sclerosis Research Laboratory, Queen's University of Belfast.
FAU - Zhou, A L
AU  - Zhou AL
FAU - McQuaid, S
AU  - McQuaid S
FAU - Cosby, S L
AU  - Cosby SL
FAU - Allen, I V
AU  - Allen IV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropathol Appl Neurobiol
JT  - Neuropathology and applied neurobiology
JID - 7609829
SB  - IM
MH  - *Cerebrovascular Circulation
MH  - Endothelium, Vascular/*microbiology/ultrastructure
MH  - Humans
MH  - Immunohistochemistry
MH  - Measles virus/*isolation & purification
MH  - Microscopy, Electron
MH  - Nucleic Acid Hybridization
MH  - Subacute Sclerosing Panencephalitis/*microbiology/pathology
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
AID - 10.1111/j.1365-2990.1991.tb00726.x [doi]
PST - ppublish
SO  - Neuropathol Appl Neurobiol. 1991 Aug;17(4):289-97. doi: 
      10.1111/j.1365-2990.1991.tb00726.x.