PMID- 19448694
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20160513
IS  - 1715-5312 (Print)
IS  - 1715-5312 (Linking)
VI  - 34
IP  - 3
DP  - 2009 Jun
TI  - Changes in muscle mass with mechanical load: possible cellular mechanisms.
PG  - 328-35
LID - 10.1139/H09-010 [doi]
AB  - Understanding the mechanisms that regulate skeletal muscle mass has remained a 
      focus of numerous researchers for many years. Recent investigations have begun to 
      elucidate cellular signaling mechanisms that regulate skeletal muscle 
      hypertrophy, with significant effort being focused on the Akt/mammalian target of 
      rapamycin (mTOR) signaling pathway. The Akt/mTOR pathway plays a major role in 
      regulating the initiation of protein synthesis after the onset of mechanical 
      loading of skeletal muscle. Although a number of downstream substrates for 
      Akt/mTOR have been elucidated, very little is known about the upstream mechanisms 
      that mechanical load employs to activate the Akt/mTOR signaling pathway. Thus, 
      the purpose of this review is to discuss potential mechanisms that may contribute 
      to the activation of the Akt/mTOR signaling mechanism in mechanically loaded 
      skeletal muscle.
FAU - Spangenburg, Espen E
AU  - Spangenburg EE
AD  - University of Maryland, School of Public Health, Department of Kinesiology, 
      College Park, MD 20742, USA. espen@umd.edu
LA  - eng
GR  - AR051396/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - Biomechanical Phenomena
MH  - Gene Expression Regulation/physiology
MH  - Humans
MH  - Muscle, Skeletal/*cytology/*physiology
MH  - Rats
MH  - Signal Transduction/*physiology
RF  - 65
EDAT- 2009/05/19 09:00
MHDA- 2009/07/30 09:00
CRDT- 2009/05/19 09:00
PHST- 2009/05/19 09:00 [entrez]
PHST- 2009/05/19 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
AID - h09-010 [pii]
AID - 10.1139/H09-010 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2009 Jun;34(3):328-35. doi: 10.1139/H09-010.