PMID- 19450143
OWN - NLM
STAT- MEDLINE
DCOM- 20090814
LR  - 20171116
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 7
IP  - 3
DP  - 2009 Jun
TI  - Association of monocyte chemoattractant protein-1 -2518 polymorphism with 
      metabolic syndrome in a South Indian cohort.
PG  - 193-8
LID - 10.1089/met.2008.0064 [doi]
AB  - BACKGROUND: Previous reports have indicated an association of monocyte 
      chemoattractant protein-1 (MCP-1) with risk factors for atherosclerosis and 
      coronary artery disease (CAD). Because some of these risk factors form components 
      of metabolic syndrome, in the present study, we investigated the association of 
      an important promoter region polymorphism of MCP-1, A-2518G, and its serum levels 
      with metabolic syndrome in a South Indian cohort. METHODS: The study comprised of 
      126 healthy subjects aged 30-59 years from South India. Subjects were classified 
      on the basis of presence or absence of metabolic syndrome and metabolic syndrome 
      components as per the International Diabetes Federation definition. MCP-1 
      genotyping was done by polymerase chain reaction restriction fragment-length 
      polymorphism, and serum levels were estimated by enzyme-linked immunosorbent 
      assay. RESULTS: The MCP-1 -2518G allele frequency in the study population was 
      32.9% and the mean MCP-1 serum levels were 523 +/- 272.3 pg/mL. Subjects with 
      metabolic syndrome showed an increased presence of the MCP-1 -2518G allele in 
      comparison to those without metabolic syndrome (odds ratio [OR] = 5.03, P = 
      0.02). The association was related to a higher proportion of this allele in 
      subjects with increased waist circumference (OR = 3.78, P = 0.05). CONCLUSIONS: 
      The MCP-1 -2518G allele may be contributing to atherosclerosis and CAD by 
      conferring an increased risk to metabolic syndrome and/or obesity.
FAU - Kaur, Savneet
AU  - Kaur S
AD  - Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for 
      Medical Sciences and Technology, Thiruvananthapuram, India.
FAU - Panicker, Sumith R
AU  - Panicker SR
FAU - James, T
AU  - James T
FAU - Sarma, P Sankara
AU  - Sarma PS
FAU - Thankappan, K R
AU  - Thankappan KR
FAU - Kartha, Chandrasekharan C
AU  - Kartha CC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Atherosclerosis/etiology
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*genetics
MH  - Cohort Studies
MH  - Coronary Artery Disease/etiology
MH  - Cross-Sectional Studies
MH  - DNA Primers/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - India
MH  - Male
MH  - Metabolic Syndrome/blood/complications/*genetics
MH  - Middle Aged
MH  - Obesity/complications
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Risk Factors
MH  - Waist Circumference
EDAT- 2009/05/20 09:00
MHDA- 2009/08/15 09:00
CRDT- 2009/05/20 09:00
PHST- 2009/05/20 09:00 [entrez]
PHST- 2009/05/20 09:00 [pubmed]
PHST- 2009/08/15 09:00 [medline]
AID - 10.1089/met.2008.0064 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2009 Jun;7(3):193-8. doi: 10.1089/met.2008.0064.