PMID- 19451201
OWN - NLM
STAT- MEDLINE
DCOM- 20091009
LR  - 20220408
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Print)
IS  - 0022-3751 (Linking)
VI  - 587
IP  - Pt 13
DP  - 2009 Jul 1
TI  - Differential effects of treadmill running and wheel running on spatial or 
      aversive learning and memory: roles of amygdalar brain-derived neurotrophic 
      factor and synaptotagmin I.
PG  - 3221-31
LID - 10.1113/jphysiol.2009.173088 [doi]
AB  - Chronic exercise has been reported to improve cognitive function. However, 
      whether and how different types of exercise affect various learning and memory 
      tasks remain uncertain. To address this issue, male BALB/c mice were trained for 
      4 weeks under two different exercise protocols: moderate treadmill running or 
      voluntary wheel running. After exercise training, their spatial memory and 
      aversive memory were evaluated by a Morris water maze and by one-trial passive 
      avoidance (PA), respectively. Levels of neural plasticity-related proteins, i.e. 
      brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) and 
      synaptotagmin I (Syt I), in hippocampus and amygdala were determined by ELISA or 
      immunoblotting. Finally, the functional roles of these proteins in the 
      basolateral amygdala were verified by locally blocking them with K252a (a TrkB 
      kinase inhibitor), or lentivirus expressing Syt I shRNA. We found that (1) 
      although both moderate treadmill running and wheel running improved the Morris 
      water maze performance, only the former improved PA performance; (2) likewise, 
      both exercise protocols upregulated the BDNF-TrkB pathway and Syt I in the 
      hippocampus, whereas only treadmill exercise upregulated their expression levels 
      in the amygdala; (3) local injection of K252a abolished the treadmill 
      exercise-facilitated PA performance and upregulation of amygdalar TrkB and Syt I; 
      and (4) local administration of Syt I shRNA abolished the treadmill 
      exercise-facilitated PA performance and upregulation of amygdalar Syt I. 
      Therefore, our results support the notion that different forms of exercise induce 
      neuroplasticity changes in different brain regions, and thus exert diverse 
      effects on various forms of learning and memory.
FAU - Liu, Yu-Fan
AU  - Liu YF
AD  - Institute of Basic Medical Sciences, Department of Physiology, National Cheng 
      Kung University, Tainan, Taiwan
FAU - Chen, Hsiun-ing
AU  - Chen HI
FAU - Wu, Chao-Liang
AU  - Wu CL
FAU - Kuo, Yu-Min
AU  - Kuo YM
FAU - Yu, Lung
AU  - Yu L
FAU - Huang, A-Min
AU  - Huang AM
FAU - Wu, Fong-Sen
AU  - Wu FS
FAU - Chuang, Jih-Ing
AU  - Chuang JI
FAU - Jen, Chauying J
AU  - Jen CJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090518
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Indole Alkaloids)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Synaptotagmin I)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Amygdala/physiology
MH  - Animals
MH  - Avoidance Learning/drug effects/physiology
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Carbazoles/pharmacology
MH  - Corticosterone/blood
MH  - Hippocampus/physiology
MH  - Indole Alkaloids/pharmacology
MH  - Learning/drug effects/*physiology
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Memory/drug effects/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Motor Activity/*physiology
MH  - Muscle, Skeletal/physiology
MH  - Neuronal Plasticity/physiology
MH  - RNA, Small Interfering/genetics
MH  - Receptor, trkB/antagonists & inhibitors/physiology
MH  - Running/physiology
MH  - Synaptotagmin I/antagonists & inhibitors/genetics/*physiology
PMC - PMC2727033
EDAT- 2009/05/20 09:00
MHDA- 2009/10/10 06:00
PMCR- 2010/07/01
CRDT- 2009/05/20 09:00
PHST- 2009/05/20 09:00 [entrez]
PHST- 2009/05/20 09:00 [pubmed]
PHST- 2009/10/10 06:00 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - jphysiol.2009.173088 [pii]
AID - 10.1113/jphysiol.2009.173088 [doi]
PST - ppublish
SO  - J Physiol. 2009 Jul 1;587(Pt 13):3221-31. doi: 10.1113/jphysiol.2009.173088. Epub 
      2009 May 18.