PMID- 19452726
OWN - NLM
STAT- MEDLINE
DCOM- 20110630
LR  - 20090520
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 23
IP  - 3
DP  - 2009 Feb
TI  - [The expression of Galectin-3 and VEGF in laryngeal squamous cell carcinoma].
PG  - 109-12
AB  - OBJECTIVE: To investigate the expression of galectin-3 and VEGF in laryngeal 
      squamous cell carcinoma (LSCC) tissue and to analyze its role in differentiation, 
      growth and metastasis of the tumor. METHOD: The expression of galectin-3 and VEGF 
      were detected with SP immunohistochemistry staining and western blot in 
      twenty-nine specimens of LSCC and eighteen specimens of laryngeal benign lesion. 
      RESULT: The expression of galectin-3 (89.7%) and VEGF (86.2%) in LSCC were 
      remarkably higher than that in normal control tissue (P<0.05), and the expression 
      of galectin-3 (89.7%) and VEGF (86.2%) in higher histodifferentiation specimens 
      were higher than that in lower histodifferentiation specimens (P<0.05). Moreover, 
      the expression level of galectin-3 and VEGF was detected a statistical positive 
      correlation (r=0.423, P<0.05) in LSCC. CONCLUSION: The high level expression of 
      galectin-3 and VEGF in LSCC could play an important role in tumorous 
      histodifferentiation and metastasis.
FAU - Kong, Hong
AU  - Kong H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union 
      Hospital of Jilin University, Changchun, 130033, China. konghong@jlu.edu.cn
FAU - Cui, Junsheng
AU  - Cui J
FAU - Wang, Lianyou
AU  - Wang L
FAU - Dong, Zhen
AU  - Dong Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Galectin 3)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Galectin 3/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Vascular Endothelial Growth Factor A/*metabolism
EDAT- 2009/05/21 09:00
MHDA- 2011/07/01 06:00
CRDT- 2009/05/21 09:00
PHST- 2009/05/21 09:00 [entrez]
PHST- 2009/05/21 09:00 [pubmed]
PHST- 2011/07/01 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Feb;23(3):109-12.