PMID- 19453942
OWN - NLM
STAT- MEDLINE
DCOM- 20090615
LR  - 20211020
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 109
IP  - 5
DP  - 2009 Jun
TI  - Escalating ethanol intake is associated with altered corticostriatal BDNF 
      expression.
PG  - 1459-68
LID - 10.1111/j.1471-4159.2009.06073.x [doi]
AB  - Alcoholism is a chronically relapsing condition, indicative of long-term neuronal 
      adaptations maintaining the disease even after prolonged abstinence. Previously, 
      we identified brain-derived neurotrophic factor (BDNF) in the dorsal striatum as 
      the central mediator of a homeostatic mechanism which is activated by acute 
      alcohol (ethanol) exposure and functions to decrease the sensitivity of rodents 
      to ethanol-related behaviors. We hypothesized that extensive exposure to ethanol 
      would result in dysregulation of this BDNF-mediated protective mechanism, 
      accompanied by heightened ethanol intake. In this study, we demonstrate that 
      while a single bout of ethanol intake increases BDNF mRNA expression in the 
      dorsal striatum, this effect is no longer observed after 6 weeks of daily ethanol 
      access. Additionally, 6 weeks of ethanol consumption decreases BDNF in the 
      cortex, a main source of BDNF for the striatum. Importantly, these 
      ethanol-induced changes in BDNF levels are not ameliorated by 2 weeks' 
      abstinence. Together, these data suggest that the BDNF pathway, which is 
      activated following a single bout of ethanol drinking, breaks down by the end of 
      6 weeks of access and does not recover its protective function after a 2-week 
      deprivation period. These results suggest that the persistence of altered BDNF 
      signaling may contribute to the inflexibility of addictive behaviors.
FAU - Logrip, Marian L
AU  - Logrip ML
AD  - The Gallo Research Center, University of California, San Francisco, Emeryville, 
      California 94608, USA.
FAU - Janak, Patricia H
AU  - Janak PH
FAU - Ron, Dorit
AU  - Ron D
LA  - eng
GR  - F31 AA015462/AA/NIAAA NIH HHS/United States
GR  - R01 AA016848/AA/NIAAA NIH HHS/United States
GR  - R01 AA016848-01A1/AA/NIAAA NIH HHS/United States
GR  - U01 AA013489/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20090328
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Alcohol Drinking/*pathology/physiopathology
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cerebral Cortex/*metabolism
MH  - Choice Behavior/physiology
MH  - Corpus Striatum/*metabolism
MH  - Food Preferences/physiology
MH  - Gene Expression Regulation/drug effects/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Self Administration
PMC - PMC2847400
MID - NIHMS106241
EDAT- 2009/05/21 09:00
MHDA- 2009/06/16 09:00
PMCR- 2010/03/30
CRDT- 2009/05/21 09:00
PHST- 2009/05/21 09:00 [entrez]
PHST- 2009/05/21 09:00 [pubmed]
PHST- 2009/06/16 09:00 [medline]
PHST- 2010/03/30 00:00 [pmc-release]
AID - JNC6073 [pii]
AID - 10.1111/j.1471-4159.2009.06073.x [doi]
PST - ppublish
SO  - J Neurochem. 2009 Jun;109(5):1459-68. doi: 10.1111/j.1471-4159.2009.06073.x. Epub 
      2009 Mar 28.