PMID- 19454386
OWN - NLM
STAT- MEDLINE
DCOM- 20100128
LR  - 20221207
IS  - 1934-2403 (Electronic)
IS  - 1530-891X (Linking)
VI  - 15
IP  - 6
DP  - 2009 Sep-Oct
TI  - Prevalence of hypogonadism in patients with type 2 diabetes mellitus in an Asian 
      Indian study group.
PG  - 513-20
LID - 10.4158/EP09035.ORR [doi]
AB  - OBJECTIVE: To determine the prevalence of hypogonadism in Asian Indian patients 
      with type 2 diabetes mellitus (T2DM) and to correlate it with components of the 
      metabolic syndrome and microvascular complications of T2DM. METHODS: One hundred 
      consecutive male patients with T2DM between 25 and 50 years of age and 50 
      age-matched healthy adults without diabetes underwent assessment. Calculated free 
      testosterone was derived by using serum total testosterone and sex 
      hormone-binding globulin. Those patients with 2 calculated free testosterone 
      values less than 64.8 pg/mL were diagnosed as having hypogonadism. RESULTS: Of 
      the 100 patients with T2DM, 15 (15%) were found to have hypogonadism-7 of 29 
      (24%) between 31 and 40 years of age and 8 of 67 (12%) between 41 and 50 years 
      old. None of the 4 patients between 25 and 30 years old had hypogonadism. Eleven 
      patients (73%) had hypogonadotropic hypogonadism, and 4 (27%) had 
      hypergonadotropic hypogonadism. Among the control subjects, the prevalence of 
      hypogonadism was 10%. In comparison with Western data, we found a higher 
      prevalence of hypogonadism in patients with T2DM, especially in those in the 4th 
      decade of life. The prevalence of hypogonadism was higher in obese patients, 
      although it did not reach statistical significance. No statistically significant 
      correlation was observed between hypogonadism and age, duration of diabetes, 
      glycemic control, androgen deficiency symptoms, or microvascular complications. 
      CONCLUSION: The prevalence of hypogonadism was higher in the patients with 
      diabetes than in the control subjects, although the difference did not reach 
      statistical significance. There was no correlation of hypogonadism with 
      components of the metabolic syndrome or microvascular complications of diabetes 
      mellitus.
FAU - Ganesh, Hosahithlu K
AU  - Ganesh HK
AD  - Division of Endocrinology, Seth Gordhandas Sunderdas Medical College and King 
      Edward Memorial Hospital, Mumbai, Maharashtra, India.
FAU - Vijaya Sarathi, H A
AU  - Vijaya Sarathi HA
FAU - George, Joe
AU  - George J
FAU - Shivane, Vyankatesh K
AU  - Shivane VK
FAU - Bandgar, Tushar
AU  - Bandgar T
FAU - Menon, Padma S
AU  - Menon PS
FAU - Shah, Nalini S
AU  - Shah NS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Lipids)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aging
MH  - Androgen-Insensitivity Syndrome/complications
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*complications/physiopathology
MH  - Glycated Hemoglobin/analysis
MH  - Gonadal Steroid Hormones/blood
MH  - Humans
MH  - Hypogonadism/complications/*epidemiology
MH  - India/epidemiology
MH  - Kidney Function Tests
MH  - Lipids/blood
MH  - Male
MH  - Matched-Pair Analysis
MH  - Metabolic Syndrome/*complications/physiopathology
MH  - Middle Aged
MH  - Obesity/complications
MH  - Pituitary Function Tests
MH  - Prevalence
MH  - Sex Hormone-Binding Globulin/analysis
EDAT- 2009/05/21 09:00
MHDA- 2010/01/29 06:00
CRDT- 2009/05/21 09:00
PHST- 2009/05/21 09:00 [entrez]
PHST- 2009/05/21 09:00 [pubmed]
PHST- 2010/01/29 06:00 [medline]
AID - S1530-891X(20)41365-5 [pii]
AID - 10.4158/EP09035.ORR [doi]
PST - ppublish
SO  - Endocr Pract. 2009 Sep-Oct;15(6):513-20. doi: 10.4158/EP09035.ORR.