PMID- 19455131
OWN - NLM
STAT- MEDLINE
DCOM- 20090623
LR  - 20240318
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 104
IP  - 6
DP  - 2009 Jun
TI  - Between celiac disease and irritable bowel syndrome: the "no man's land" of 
      gluten sensitivity.
PG  - 1587-94
LID - 10.1038/ajg.2009.188 [doi]
AB  - The repertoire of gastrointestinal (GI) symptoms is finite; however, the 
      etiologies and mechanisms underlying symptom generation and perception are 
      diverse and, in many cases, unknown. This review examines the clinical and 
      experimental evidence exploring the putative relationship between gluten 
      sensitivity (GS) and the generation of GI symptoms. It explores the hypothesis 
      that, in a proportion of patients, GS causes functional bowel disorder (FBD)-like 
      symptoms. We propose a model for investigating and understanding the induction of 
      GI symptoms and dysfunction by gluten in FBD and organic disease. We hypothesize 
      that, even in the absence of fully developed celiac disease, gluten can induce 
      symptoms similar to FBD. We discuss the hypothesis that GS and post-infectious 
      irritable bowel syndrome (IBS) provide two triggers that can explain at least 
      part of the spectrum that constitutes IBS, further advancing an understanding of 
      the role of mucosal responses to luminal factors in FBDs. We propose that the 
      animal model of GS in human leukocyte antigen (HLA)- DQ8 mice allows 
      investigation of mucosal pathophysiological changes that occur before the onset 
      of full-blown inflammation in a GS host. A better understanding of how gluten can 
      cause symptoms in sensitive individuals will illuminate the interaction between 
      host genotype, diet, and intestinal microbiota in generating one of the most 
      common GI conditions.
FAU - Verdu, Elena F
AU  - Verdu EF
AD  - Farncombe Family Digestive Health Research Institute, Department of Medicine, 
      McMaster University, Hamilton, Ontario, Canada.
FAU - Armstrong, David
AU  - Armstrong D
FAU - Murray, Joseph A
AU  - Murray JA
LA  - eng
GR  - R01 DK057892/DK/NIDDK NIH HHS/United States
GR  - R01 DK071003/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 8002-80-0 (Glutens)
SB  - IM
CIN - Am J Gastroenterol. 2010 Jan;105(1):222-3; author reply 223-4. PMID: 20054311
MH  - Animals
MH  - Celiac Disease/*etiology
MH  - Glutens/*adverse effects
MH  - Humans
MH  - Irritable Bowel Syndrome/*etiology
MH  - Prognosis
MH  - Risk Factors
PMC - PMC3480312
MID - NIHMS410300
EDAT- 2009/05/21 09:00
MHDA- 2009/06/24 09:00
PMCR- 2012/10/24
CRDT- 2009/05/21 09:00
PHST- 2009/05/21 09:00 [entrez]
PHST- 2009/05/21 09:00 [pubmed]
PHST- 2009/06/24 09:00 [medline]
PHST- 2012/10/24 00:00 [pmc-release]
AID - ajg2009188 [pii]
AID - 10.1038/ajg.2009.188 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2009 Jun;104(6):1587-94. doi: 10.1038/ajg.2009.188.