PMID- 19456367
OWN - NLM
STAT- MEDLINE
DCOM- 20090610
LR  - 20220331
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1163
DP  - 2009 Apr
TI  - Cadmium induces apoptosis in the pituitary gland of Podarcis sicula.
PG  - 386-8
LID - 10.1111/j.1749-6632.2008.03667.x [doi]
AB  - The cytotoxic effects of cadmium (Cd) on the pituitary gland were studied in the 
      lizard Podarcis sicula. Adult lizards were treated intraperitoneally with a 
      single injection of CdCl(2) at the dose of 2 mg/kg. A morphological study was 
      performed by terminal deoxynucleotidyl transferase-mediated dUTP nick end 
      labeling (TUNEL) technique and by immunocytochemical demonstration of caspase-3 
      for detecting apoptotic cells in situ after 2, 7, and 16 days of treatment. The 
      pituitary cells of Cd-treated P. sicula undergo apoptosis: after 2 days the 
      apoptotic cells appeared to increase significantly compared with those of the 
      control specimens; after 7 days there was no considerable increment; however, 
      after 16 days the occurrence of apoptotic cells had increased markedly, above all 
      in the rostral pars distalis (RPD) in which various cells showed a strongly 
      immunostained nucleus by TUNEL. Cd appears particularly toxic for pituitary cells 
      in the lizard P. sicula; a single high intraperitoneal dose of CdCl(2) induces 
      apoptosis, in particular in the RPD, and this effect appears irreversible.
FAU - Ferrandino, Ida
AU  - Ferrandino I
AD  - Department of Biological Sciences, Section of Evolutionary and Comparative 
      Biology, University Federico II of Naples, Naples, Italy. ida.ferrandino@unina.it
FAU - Favorito, Rossana
AU  - Favorito R
FAU - Annunziata, Martina
AU  - Annunziata M
FAU - Grimaldi, Maria Consiglio
AU  - Grimaldi MC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 00BH33GNGH (Cadmium)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cadmium/*pharmacology
MH  - Pituitary Gland/*cytology/*drug effects
MH  - *Vertebrates
EDAT- 2009/05/22 09:00
MHDA- 2009/06/11 09:00
CRDT- 2009/05/22 09:00
PHST- 2009/05/22 09:00 [entrez]
PHST- 2009/05/22 09:00 [pubmed]
PHST- 2009/06/11 09:00 [medline]
AID - NYAS03667 [pii]
AID - 10.1111/j.1749-6632.2008.03667.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2009 Apr;1163:386-8. doi: 10.1111/j.1749-6632.2008.03667.x.