PMID- 19458217
OWN - NLM
STAT- MEDLINE
DCOM- 20090608
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 20
DP  - 2009 May 20
TI  - The role of neurotrophins in the seasonal-like growth of the avian song control 
      system.
PG  - 6461-71
LID - 10.1523/JNEUROSCI.0638-09.2009 [doi]
AB  - The avian song control system undergoes pronounced seasonal plasticity in 
      response to photoperiod and hormonal cues. The action of testosterone (T) and its 
      metabolites in the song nucleus HVC is both necessary and sufficient to promote 
      breeding season-like growth of its efferent nuclei RA (robust nucleus of the 
      arcopallium) and Area X, suggesting that HVC may release a trophic factor such as 
      brain-derived neurotrophic factor (BDNF) into RA and X. BDNF is involved in many 
      forms of adult neural plasticity in other systems and is present in the avian 
      song system. We used a combination of in situ hybridization and intracerebral 
      infusions to test whether BDNF plays a role in the seasonal-like growth of the 
      song system in adult male white-crowned sparrows. BDNF mRNA levels increased in 
      HVC in response to breeding conditions, and BDNF infusion into RA was sufficient 
      to promote breeding-like changes in somatic area and neuronal density. Expression 
      of the mRNA for the Trk B receptor of BDNF, however, did not vary with seasonal 
      conditions in either HVC or RA. Local blockade of BDNF activity in RA via 
      infusion of Trk-Fc fusion proteins inhibited the response to breeding conditions. 
      Our results indicate that BDNF is sufficient to promote the seasonal plasticity 
      in somatic area and cell density in RA, although NT-3 may also contribute to this 
      process, and suggest that HVC may be a presynaptic source of increased levels of 
      BDNF in RA of breeding-condition birds.
FAU - Wissman, Anne Marie
AU  - Wissman AM
AD  - Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, 
      Washington 98195, USA. a-wissman@northwestern.edu
FAU - Brenowitz, Eliot A
AU  - Brenowitz EA
LA  - eng
GR  - P30 DC004661/DC/NIDCD NIH HHS/United States
GR  - P30DC04661/DC/NIDCD NIH HHS/United States
GR  - R01 MH053032-14/MH/NIMH NIH HHS/United States
GR  - P30 DC004661-09/DC/NIDCD NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - MH53032/MH/NIMH NIH HHS/United States
GR  - R01 MH053032/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Androgens)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drug Implants)
RN  - 0 (Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (oncogene protein trk)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Analysis of Variance
MH  - Androgens/*administration & dosage/blood
MH  - Animals
MH  - Brain/*drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Routes
MH  - Drug Implants
MH  - Gene Expression Regulation/drug effects
MH  - Male
MH  - Oncogene Proteins/administration & dosage
MH  - RNA, Messenger/metabolism
MH  - Radioimmunoassay/methods
MH  - Receptor, trkB/genetics/metabolism
MH  - *Seasons
MH  - Sparrows/*physiology
MH  - Testosterone/*administration & dosage/blood
MH  - Vocalization, Animal/*drug effects/physiology
PMC - PMC2731294
MID - NIHMS119152
EDAT- 2009/05/22 09:00
MHDA- 2009/06/09 09:00
PMCR- 2009/11/20
CRDT- 2009/05/22 09:00
PHST- 2009/05/22 09:00 [entrez]
PHST- 2009/05/22 09:00 [pubmed]
PHST- 2009/06/09 09:00 [medline]
PHST- 2009/11/20 00:00 [pmc-release]
AID - 29/20/6461 [pii]
AID - 3472135 [pii]
AID - 10.1523/JNEUROSCI.0638-09.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 May 20;29(20):6461-71. doi: 10.1523/JNEUROSCI.0638-09.2009.