PMID- 19458388
OWN - NLM
STAT- MEDLINE
DCOM- 20090903
LR  - 20120105
IS  - 1533-1601 (Electronic)
IS  - 0192-6233 (Linking)
VI  - 37
IP  - 4
DP  - 2009 Jun
TI  - The metrial gland in the rat and its similarities to granular cell tumors.
PG  - 474-80
LID - 10.1177/0192623309335632 [doi]
AB  - Metrial glands are normal structures located in the mesometrial triangle of the 
      pregnant rat uterus from gestational day (GD) 8 through termination of pregnancy. 
      Metrial glands are composed of a dynamic mixed cell population of granulated 
      metrial gland (GMG) cells, endometrial stromal cells, trophoblasts, blood 
      vessels, and fibroblasts. Collections of similar cells may be seen in association 
      with pseudopregnancy and other hormonal disturbances. Granulated metrial gland 
      cells are the hallmark cell of the metrial gland. They are bone-marrow-derived, 
      perforin-positive, natural killer cells that proliferate in the pregnant uterus. 
      Understanding the normal histogenesis of the metrial gland and recognizing the 
      possible existence of GMG cells and a reactive metrial gland in the nonpregnant 
      state are important when examining any uterine lesion that contains granulated 
      cells. This report demonstrates that the cellular composition, morphology, and 
      immunohistochemical staining profile of normal metrial glands are similar to 
      reported granular cell neoplasms in rats and mice. The possibility of a 
      non-neoplastic lesion involving the metrial gland should be considered when 
      proliferative lesions involving granulated cells are observed in the uterus of 
      mice and rats from nonclinical toxicity studies. Positive immunohistochemical 
      staining for perforin and S100 would assist in the classification of such lesions 
      as a reactive metrial gland or decidual reaction.
FAU - Picut, Catherine A
AU  - Picut CA
AD  - WIL Research Laboratories-Biotechnics, L.L.C., Hillsborough, NC 27278, USA. 
      cpicut@biotechnics-inc.com
FAU - Swanson, Cynthia L
AU  - Swanson CL
FAU - Parker, Regina F
AU  - Parker RF
FAU - Scully, Kathryn L
AU  - Scully KL
FAU - Parker, George A
AU  - Parker GA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Toxicol Pathol
JT  - Toxicologic pathology
JID - 7905907
RN  - 0 (Pore Forming Cytotoxic Proteins)
RN  - 0 (S100 Proteins)
RN  - 0 (perforin, rat)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Animals
MH  - Female
MH  - Granular Cell Tumor/*pathology
MH  - Immunohistochemistry
MH  - Metrial Gland/*chemistry/*cytology
MH  - Mice
MH  - Phosphopyruvate Hydratase/analysis
MH  - Pore Forming Cytotoxic Proteins/analysis
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - S100 Proteins/metabolism
EDAT- 2009/05/22 09:00
MHDA- 2009/09/04 06:00
CRDT- 2009/05/22 09:00
PHST- 2009/05/22 09:00 [entrez]
PHST- 2009/05/22 09:00 [pubmed]
PHST- 2009/09/04 06:00 [medline]
AID - 37/4/474 [pii]
AID - 10.1177/0192623309335632 [doi]
PST - ppublish
SO  - Toxicol Pathol. 2009 Jun;37(4):474-80. doi: 10.1177/0192623309335632.