PMID- 19458951
OWN - NLM
STAT- MEDLINE
DCOM- 20100111
LR  - 20211020
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 19
IP  - 11
DP  - 2009 Nov
TI  - Acute myocarditis in a rat model: late gadolinium enhancement with 
      histopathological correlation.
PG  - 2672-8
LID - 10.1007/s00330-009-1454-y [doi]
AB  - The aim of the current study was to use an established animal model of autoimmune 
      myocarditis and to judge the ability of cardiovascular MRI (CMR) in 
      quantitatively measuring the extent of myocardial involvement compared with 
      histopathological measurement of severity and extent. Experimental autoimmune 
      myocarditis (EAM) was induced in 10 male Lewis rats. On day 21, all animals were 
      investigated by CMR to measure the extent of late gadolinium enhancement (LGE). 
      Subsequently, histopathological evaluation of the entire heart was performed. All 
      animals of the experimental group fulfilled histopathological criteria of 
      myocarditis, revealing necrosis in seven of eight cases. At reduced heart rate, 
      area of LGE correlated highly with histologically proven area of myocarditis (r = 
      0.80-0.87, p < 0.05). LGE was mainly located in the anterior (range 50-62.5%) and 
      lateral (range 62.5-75%) left ventricular wall and septum (range 25-50%) with a 
      midwall to subepicardial accentuation. The LGE pattern found by CMR can be 
      regarded as suggestive of EAM. With cellular necrosis being the main mechanism 
      for LGE we were able to show high correlations between CMR examination results 
      and histopathologically proven areas of myocarditis. Thus we think the current 
      animal model can provide the opportunity for further fundamental research into 
      myocarditis.
FAU - Korkusuz, Huedayi
AU  - Korkusuz H
AD  - Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe 
      University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. 
      huedayi.korkusuz@kgu.de
FAU - Esters, Philip
AU  - Esters P
FAU - Naguib, Nagy
AU  - Naguib N
FAU - Nour Eldin, N-E
AU  - Nour Eldin NE
FAU - Lindemayr, Sebastian
AU  - Lindemayr S
FAU - Huebner, Frank
AU  - Huebner F
FAU - Koujan, Ahmed
AU  - Koujan A
FAU - Bug, Reinhold
AU  - Bug R
FAU - Ackermann, Hanns
AU  - Ackermann H
FAU - Vogl, Thomas J
AU  - Vogl TJ
LA  - eng
PT  - Journal Article
DEP - 20090521
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Autoimmune Diseases/diagnosis/pathology
MH  - Contrast Media/pharmacology
MH  - Disease Models, Animal
MH  - *Gadolinium
MH  - Heart Septum/pathology
MH  - Heart Ventricles/pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Myocarditis/diagnosis/*pathology
MH  - Necrosis
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Swine
EDAT- 2009/05/22 09:00
MHDA- 2010/01/12 06:00
CRDT- 2009/05/22 09:00
PHST- 2008/10/14 00:00 [received]
PHST- 2009/03/26 00:00 [accepted]
PHST- 2009/03/17 00:00 [revised]
PHST- 2009/05/22 09:00 [entrez]
PHST- 2009/05/22 09:00 [pubmed]
PHST- 2010/01/12 06:00 [medline]
AID - 10.1007/s00330-009-1454-y [doi]
PST - ppublish
SO  - Eur Radiol. 2009 Nov;19(11):2672-8. doi: 10.1007/s00330-009-1454-y. Epub 2009 May 
      21.