PMID- 19460425
OWN - NLM
STAT- MEDLINE
DCOM- 20090812
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 27
IP  - 5
DP  - 2009 Aug
TI  - Effects of maternal separation on dynamics of urocortin 1 and brain-derived 
      neurotrophic factor in the rat non-preganglionic Edinger-Westphal nucleus.
PG  - 439-51
LID - 10.1016/j.ijdevneu.2009.05.006 [doi]
AB  - Although mood disorders are frequently genetically determined and to some degree 
      gender-dependent, the concept of early life 'programming', implying a relation 
      between perinatal environmental events and adult mood disorders, has recently 
      gained considerable attention. In particular, maternal separation (MS) markedly 
      affects various stress-sensitive brain centers. Therefore, MS is considered as a 
      suitable experimental paradigm to study how early life events affect brain 
      plasticity and, hence, cause psychopathologies like major depression. In adult 
      mammals, the classical hypothalamo-pituitary-adrenal (HPA-) axis and the 
      urocortin 1 (Ucn1)-containing non-preganglionic Edinger-Westphal nucleus (npEW) 
      respond in opposite ways to chronic stressors. This raises the hypothesis that 
      MS, which is known to increase vulnerability for adult mood disorders via the 
      dysregulation of the HPA-axis, will affect npEW dynamics as well. We have tested 
      this hypothesis and, moreover, studied a possible role of brain-derived 
      neurotrophic factor (BDNF) in such npEW plasticity. By triple immunocytochemistry 
      we show that BDNF and Ucn1 coexist in rat npEW-neurons that are c-Fos-positive 
      upon acute stress. Quantitative immunocytochemistry revealed that MS increases 
      the contents of Ucn1 and BDNF in these cells. Furthermore, in males and females, 
      the c-Fos response of npEW-Ucn1 neurons upon restraint stress was blunted in 
      animals with MS history, a phenomenon that was concomitant with dampening of the 
      HPA corticosterone response in females but not in males. Based on these data we 
      suggest that the BDNF-containing npEW-Ucn1 system might be affected by MS in a 
      sex-specific manner. This supports the idea that the npEW would play a role in 
      the appearance of sex differences in the pathogenesis of stress-induced mood 
      disorders.
FAU - Gaszner, Balazs
AU  - Gaszner B
AD  - Department of Cellular Animal Physiology, Donders Centre for Neuroscience, EURON, 
      Radboud University Nijmegen, Nijmegen, The Netherlands.
FAU - Jensen, Kai-Ole
AU  - Jensen KO
FAU - Farkas, Jozsef
AU  - Farkas J
FAU - Reglodi, Dora
AU  - Reglodi D
FAU - Csernus, Valer
AU  - Csernus V
FAU - Roubos, Eric W
AU  - Roubos EW
FAU - Kozicz, Tamas
AU  - Kozicz T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090519
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Urocortins)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adaptation, Physiological
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/blood
MH  - Female
MH  - Hypothalamo-Hypophyseal System/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - *Maternal Deprivation
MH  - Mesencephalon/*metabolism
MH  - Microscopy, Fluorescence
MH  - Pituitary-Adrenal System/metabolism
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Factors
MH  - Urocortins/*metabolism
EDAT- 2009/05/23 09:00
MHDA- 2009/08/13 09:00
CRDT- 2009/05/23 09:00
PHST- 2008/11/26 00:00 [received]
PHST- 2009/04/01 00:00 [revised]
PHST- 2009/05/12 00:00 [accepted]
PHST- 2009/05/23 09:00 [entrez]
PHST- 2009/05/23 09:00 [pubmed]
PHST- 2009/08/13 09:00 [medline]
AID - S0736-5748(09)00071-9 [pii]
AID - 10.1016/j.ijdevneu.2009.05.006 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2009 Aug;27(5):439-51. doi: 10.1016/j.ijdevneu.2009.05.006. 
      Epub 2009 May 19.